2hxm

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[[Image:2hxm.gif|left|200px]]
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{{Seed}}
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{{STRUCTURE_2hxm| PDB=2hxm | SCENE= }}
{{STRUCTURE_2hxm| PDB=2hxm | SCENE= }}
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'''Complex of UNG2 and a small Molecule synthetic Inhibitor'''
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===Complex of UNG2 and a small Molecule synthetic Inhibitor===
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==Overview==
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Human nuclear uracil DNA glycosylase (UNG2) is a cellular DNA repair enzyme that is essential for a number of diverse biological phenomena ranging from antibody diversification to B-cell lymphomas and type-1 human immunodeficiency virus infectivity. During each of these processes, UNG2 recognizes uracilated DNA and excises the uracil base by flipping it into the enzyme active site. We have taken advantage of the extrahelical uracil recognition mechanism to build large small-molecule libraries in which uracil is tethered via flexible alkane linkers to a collection of secondary binding elements. This high-throughput synthesis and screening approach produced two novel uracil-tethered inhibitors of UNG2, the best of which was crystallized with the enzyme. Remarkably, this inhibitor mimics the crucial hydrogen bonding and electrostatic interactions previously observed in UNG2 complexes with damaged uracilated DNA. Thus, the environment of the binding site selects for library ligands that share these DNA features. This is a general approach to rapid discovery of inhibitors of enzymes that recognize extrahelical damaged bases.
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(as it appears on PubMed at http://www.pubmed.gov), where 17062624 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17062624}}
==About this Structure==
==About this Structure==
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[[Category: Uracil]]
[[Category: Uracil]]
[[Category: Uracil dna glycosylase]]
[[Category: Uracil dna glycosylase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 06:50:16 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 08:21:53 2008''

Revision as of 05:21, 29 July 2008

Image:2hxm.png

Template:STRUCTURE 2hxm

Complex of UNG2 and a small Molecule synthetic Inhibitor

Template:ABSTRACT PUBMED 17062624

About this Structure

2HXM is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Mimicking damaged DNA with a small molecule inhibitor of human UNG2., Krosky DJ, Bianchet MA, Seiple L, Chung S, Amzel LM, Stivers JT, Nucleic Acids Res. 2006;34(20):5872-9. Epub 2006 Oct 24. PMID:17062624

Page seeded by OCA on Tue Jul 29 08:21:53 2008

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