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2hyi

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[[Image:2hyi.gif|left|200px]]
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{{STRUCTURE_2hyi| PDB=2hyi | SCENE= }}
{{STRUCTURE_2hyi| PDB=2hyi | SCENE= }}
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'''Structure of the human exon junction complex with a trapped DEAD-box helicase bound to RNA'''
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===Structure of the human exon junction complex with a trapped DEAD-box helicase bound to RNA===
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==Overview==
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In higher eukaryotes, a multiprotein exon junction complex is deposited on spliced messenger RNAs. The complex is organized around a stable core, which serves as a binding platform for numerous factors that influence messenger RNA function. Here, we present the crystal structure of a tetrameric exon junction core complex containing the DEAD-box adenosine triphosphatase (ATPase) eukaryotic initiation factor 4AIII (eIF4AIII) bound to an ATP analog, MAGOH, Y14, a fragment of MLN51, and a polyuracil mRNA mimic. eIF4AIII interacts with the phosphate-ribose backbone of six consecutive nucleotides and prevents part of the bound RNA from being double stranded. The MAGOH and Y14 subunits lock eIF4AIII in a prehydrolysis state, and activation of the ATPase probably requires only modest conformational changes in eIF4AIII motif I.
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(as it appears on PubMed at http://www.pubmed.gov), where 16931718 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16931718}}
==About this Structure==
==About this Structure==
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[[Category: Splicing]]
[[Category: Splicing]]
[[Category: Translation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 06:52:02 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 23:56:03 2008''

Revision as of 20:56, 27 July 2008

Image:2hyi.png

Template:STRUCTURE 2hyi

Structure of the human exon junction complex with a trapped DEAD-box helicase bound to RNA

Template:ABSTRACT PUBMED 16931718

About this Structure

2HYI is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of the exon junction core complex with a trapped DEAD-box ATPase bound to RNA., Andersen CB, Ballut L, Johansen JS, Chamieh H, Nielsen KH, Oliveira CL, Pedersen JS, Seraphin B, Le Hir H, Andersen GR, Science. 2006 Sep 29;313(5795):1968-72. Epub 2006 Aug 24. PMID:16931718

Page seeded by OCA on Sun Jul 27 23:56:03 2008

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