2hzd

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[[Image:2hzd.gif|left|200px]]
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{{STRUCTURE_2hzd| PDB=2hzd | SCENE= }}
{{STRUCTURE_2hzd| PDB=2hzd | SCENE= }}
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'''NMR structure of the DNA-binding TEA domain and insights into TEF-1 function'''
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===NMR structure of the DNA-binding TEA domain and insights into TEF-1 function===
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==Overview==
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Transcription enhancer factor 1 is essential for cardiac, skeletal, and smooth muscle development and uses its N-terminal TEA domain (TEAD) to bind M-CAT elements. Here, we present the first structure of TEAD and show that it is a three-helix bundle with a homeodomain fold. Structural data reveal how TEAD binds DNA. Using structure-function correlations, we find that the L1 loop is essential for cooperative loading of TEAD molecules on to tandemly duplicated M-CAT sites. Furthermore, using a microarray chip-based assay, we establish that known binding sites of the full-length protein are only a subset of DNA elements recognized by TEAD. Our results provide a model for understanding the regulation of genome-wide gene expression during development by TEA/ATTS family of transcription factors.
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(as it appears on PubMed at http://www.pubmed.gov), where 17085591 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17085591}}
==About this Structure==
==About this Structure==
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2HZD is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HZD OCA].
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2HZD is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HZD OCA].
==Reference==
==Reference==
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[[Category: Dna-binding]]
[[Category: Dna-binding]]
[[Category: Helix-turn-helix]]
[[Category: Helix-turn-helix]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 06:53:48 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 16:07:22 2008''

Revision as of 13:07, 28 July 2008

Image:2hzd.png

Template:STRUCTURE 2hzd

NMR structure of the DNA-binding TEA domain and insights into TEF-1 function

Template:ABSTRACT PUBMED 17085591

About this Structure

2HZD is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

Insights into transcription enhancer factor 1 (TEF-1) activity from the solution structure of the TEA domain., Anbanandam A, Albarado DC, Nguyen CT, Halder G, Gao X, Veeraraghavan S, Proc Natl Acad Sci U S A. 2006 Nov 14;103(46):17225-30. Epub 2006 Nov 3. PMID:17085591

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