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2hzs

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[[Image:2hzs.gif|left|200px]]
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{{STRUCTURE_2hzs| PDB=2hzs | SCENE= }}
{{STRUCTURE_2hzs| PDB=2hzs | SCENE= }}
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'''Structure of the Mediator head submodule Med8C/18/20'''
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===Structure of the Mediator head submodule Med8C/18/20===
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==Overview==
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The Mediator head module stimulates basal RNA polymerase II (Pol II) transcription and enables transcriptional regulation. Here we show that the head subunits Med8, Med18 and Med20 form a subcomplex (Med8/18/20) with two submodules. The highly conserved N-terminal domain of Med8 forms one submodule that binds the TATA box-binding protein (TBP) in vitro and is essential in vivo. The second submodule consists of the C-terminal region of Med8 (Med8C), Med18 and Med20. X-ray analysis of this submodule reveals that Med18 and Med20 form related beta-barrel folds. A conserved putative protein-interaction face on the Med8C/18/20 submodule includes sites altered by srb mutations, which counteract defects resulting from Pol II truncation. Our results and published data support a positive role of the Med8/18/20 subcomplex in initiation-complex formation and suggest that the Mediator head contains a multipartite TBP-binding site that can be modulated by transcriptional activators.
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(as it appears on PubMed at http://www.pubmed.gov), where 16964259 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16964259}}
==About this Structure==
==About this Structure==
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 06:54:39 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 08:55:58 2008''

Revision as of 05:56, 29 July 2008

Image:2hzs.png

Template:STRUCTURE 2hzs

Structure of the Mediator head submodule Med8C/18/20

Template:ABSTRACT PUBMED 16964259

About this Structure

2HZS is a Protein complex structure of sequences from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

Structure and TBP binding of the Mediator head subcomplex Med8-Med18-Med20., Lariviere L, Geiger S, Hoeppner S, Rother S, Strasser K, Cramer P, Nat Struct Mol Biol. 2006 Oct;13(10):895-901. Epub 2006 Sep 10. PMID:16964259

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