2hzv

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{{STRUCTURE_2hzv| PDB=2hzv | SCENE= }}
{{STRUCTURE_2hzv| PDB=2hzv | SCENE= }}
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'''NikR-operator DNA complex'''
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===NikR-operator DNA complex===
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==Overview==
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Metal ion homeostasis is critical to the survival of all cells. Regulation of nickel concentrations in Escherichia coli is mediated by the NikR repressor via nickel-induced transcriptional repression of the nickel ABC-type transporter, NikABCDE. Here, we report two crystal structures of nickel-activated E. coli NikR, the isolated repressor at 2.1 A resolution and in a complex with its operator DNA sequence from the nik promoter at 3.1 A resolution. Along with the previously published structure of apo-NikR, these structures allow us to evaluate functional proposals for how metal ions activate NikR, delineate the drastic conformational changes required for operator recognition, and describe the formation of a second metal-binding site in the presence of DNA. They also provide a rare set of structural views of a ligand-responsive transcription factor in the unbound, ligand-induced, and DNA-bound states, establishing a model system for the study of ligand-mediated effects on transcription factor function.
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==About this Structure==
==About this Structure==
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[[Category: Ribbon-helix-helix]]
[[Category: Ribbon-helix-helix]]
[[Category: Transcription factor]]
[[Category: Transcription factor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 19:50:56 2008''

Revision as of 16:51, 27 July 2008

Image:2hzv.png

Template:STRUCTURE 2hzv

NikR-operator DNA complex

Template:ABSTRACT PUBMED 16945905

About this Structure

2HZV is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

NikR-operator complex structure and the mechanism of repressor activation by metal ions., Schreiter ER, Wang SC, Zamble DB, Drennan CL, Proc Natl Acad Sci U S A. 2006 Sep 12;103(37):13676-81. Epub 2006 Aug 31. PMID:16945905

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