This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


2i1r

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:2i1r.jpg|left|200px]]
+
{{Seed}}
 +
[[Image:2i1r.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_2i1r| PDB=2i1r | SCENE= }}
{{STRUCTURE_2i1r| PDB=2i1r | SCENE= }}
-
'''Novel Thiazolones as HCV NS5B Polymerase Inhibitors: Further Designs, Synthesis, SAR and X-ray Complex Structure'''
+
===Novel Thiazolones as HCV NS5B Polymerase Inhibitors: Further Designs, Synthesis, SAR and X-ray Complex Structure===
-
==Overview==
+
<!--
-
Structure-activity relationships (SAR) of 1 against HCV NS5B polymerase were described. SAR explorations and further structure-based design led to the identifications of 2 and 3 as novel HCV NS5B inhibitors. X-ray structure of 3 in complex with NS5B polymerase was obtained at a resolution of 2.2A, and confirmed the design.
+
The line below this paragraph, {{ABSTRACT_PUBMED_17049849}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 17049849 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_17049849}}
==About this Structure==
==About this Structure==
Line 31: Line 35:
[[Category: Rdrp]]
[[Category: Rdrp]]
[[Category: Viral rna-directed rna polymerase]]
[[Category: Viral rna-directed rna polymerase]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 06:58:16 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 23:36:43 2008''

Revision as of 20:36, 27 July 2008

Image:2i1r.png

Template:STRUCTURE 2i1r

Novel Thiazolones as HCV NS5B Polymerase Inhibitors: Further Designs, Synthesis, SAR and X-ray Complex Structure

Template:ABSTRACT PUBMED 17049849

About this Structure

2I1R is a Single protein structure of sequence from Hepatitis c virus. Full crystallographic information is available from OCA.

Reference

Novel thiazolones as HCV NS5B polymerase allosteric inhibitors: Further designs, SAR, and X-ray complex structure., Yan S, Larson G, Wu JZ, Appleby T, Ding Y, Hamatake R, Hong Z, Yao N, Bioorg Med Chem Lett. 2007 Jan 1;17(1):63-7. Epub 2006 Oct 4. PMID:17049849

Page seeded by OCA on Sun Jul 27 23:36:43 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2i1r"
Personal tools