2i28

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[[Image:2i28.jpg|left|200px]]
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[[Image:2i28.png|left|200px]]
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{{STRUCTURE_2i28| PDB=2i28 | SCENE= }}
{{STRUCTURE_2i28| PDB=2i28 | SCENE= }}
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'''Solution Structure of alpha-Conotoxin BuIA'''
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===Solution Structure of alpha-Conotoxin BuIA===
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==Overview==
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We have determined a high-resolution three-dimensional structure of alpha-conotoxin BuIA, a 13-residue peptide toxin isolated from Conus bullatus. Despite its unusual 4/4 disulfide bond layout alpha-conotoxin BuIA exhibits strong antagonistic activity at alpha6/alpha3beta2beta3, alpha3beta2, and alpha3beta4 nAChR subtypes like some alpha4/7 conotoxins. alpha-Conotoxin BuIA lacks the C-terminal beta-turn present within the second disulfide loop of alpha4/7 conotoxins, having only a "pseudo omega-shaped" molecular topology. Nevertheless, it contains a functionally critical two-turn helix motif, a feature ubiquitously found in alpha4/7 conotoxins. Such an aspect seems mainly responsible for similarities in the receptor recognition profile of alpha-conotoxin BuIA to alpha4/7 conotoxins. Structural comparison of alpha-conotoxin BuIA with alpha4/7 conotoxins and alpha4/3 conotoxin ImI suggests that presence of the second helical turn portion of the two-turn helix motif in alpha4/7 and alpha4/4 conotoxins may be important for binding to the alpha3 and/or alpha6 subunit of nAChR.
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The line below this paragraph, {{ABSTRACT_PUBMED_16979596}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 16979596 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16979596}}
==About this Structure==
==About this Structure==
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2I28 is a [[Single protein]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I28 OCA].
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2I28 is a [[Single protein]] structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I28 OCA].
==Reference==
==Reference==
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[[Category: C-terminal amidation]]
[[Category: C-terminal amidation]]
[[Category: Two disulfide bond]]
[[Category: Two disulfide bond]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 06:59:25 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 10:07:51 2008''

Revision as of 07:07, 29 July 2008

Image:2i28.png

Template:STRUCTURE 2i28

Solution Structure of alpha-Conotoxin BuIA

Template:ABSTRACT PUBMED 16979596

About this Structure

2I28 is a Single protein structure. Full experimental information is available from OCA.

Reference

NMR structure determination of alpha-conotoxin BuIA, a novel neuronal nicotinic acetylcholine receptor antagonist with an unusual 4/4 disulfide scaffold., Chi SW, Kim DH, Olivera BM, McIntosh JM, Han KH, Biochem Biophys Res Commun. 2006 Nov 3;349(4):1228-34. Epub 2006 Sep 7. PMID:16979596

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