2i37

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{{STRUCTURE_2i37| PDB=2i37 | SCENE= }}
{{STRUCTURE_2i37| PDB=2i37 | SCENE= }}
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'''Crystal structure of a photoactivated rhodopsin'''
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===Crystal structure of a photoactivated rhodopsin===
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==Overview==
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The changes that lead to activation of G protein-coupled receptors have not been elucidated at the structural level. In this work we report the crystal structures of both ground state and a photoactivated deprotonated intermediate of bovine rhodopsin at a resolution of 4.15 A. In the photoactivated state, the Schiff base linking the chromophore and Lys-296 becomes deprotonated, reminiscent of the G protein-activating state, metarhodopsin II. The structures reveal that the changes that accompany photoactivation are smaller than previously predicted for the metarhodopsin II state and include changes on the cytoplasmic surface of rhodopsin that possibly enable the coupling to its cognate G protein, transducin. Furthermore, rhodopsin forms a potentially physiologically relevant dimer interface that involves helices I, II, and 8, and when taken with the prior work that implicates helices IV and V as the physiological dimer interface may account for one of the interfaces of the oligomeric structure of rhodopsin seen in the membrane by atomic force microscopy. The activation and oligomerization models likely extend to the majority of other G protein-coupled receptors.
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{{ABSTRACT_PUBMED_17060607}}
==About this Structure==
==About this Structure==
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[[Category: Gpcr]]
[[Category: Gpcr]]
[[Category: Trans-membrane protein]]
[[Category: Trans-membrane protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 07:01:00 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 06:42:20 2008''

Revision as of 03:42, 28 July 2008

Image:2i37.png

Template:STRUCTURE 2i37

Crystal structure of a photoactivated rhodopsin

Template:ABSTRACT PUBMED 17060607

About this Structure

2I37 is a Single protein structure of sequence from Bos taurus. Full crystallographic information is available from OCA.

Reference

Crystal structure of a photoactivated deprotonated intermediate of rhodopsin., Salom D, Lodowski DT, Stenkamp RE, Le Trong I, Golczak M, Jastrzebska B, Harris T, Ballesteros JA, Palczewski K, Proc Natl Acad Sci U S A. 2006 Oct 31;103(44):16123-8. Epub 2006 Oct 23. PMID:17060607

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