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2i39

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{{STRUCTURE_2i39| PDB=2i39 | SCENE= }}
{{STRUCTURE_2i39| PDB=2i39 | SCENE= }}
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'''Crystal structure of Vaccinia virus N1L protein'''
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===Crystal structure of Vaccinia virus N1L protein===
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==Overview==
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Poxviruses encode immuno-modulatory proteins capable of subverting host defenses. The poxvirus vaccinia expresses a small 14-kDa protein, N1L, that is critical for virulence. We report the crystal structure of N1L, which reveals an unexpected but striking resemblance to host apoptotic regulators of the B cell lymphoma-2 (Bcl-2) family. Although N1L lacks detectable Bcl-2 homology (BH) motifs at the sequence level, we show that N1L binds with high affinity to the BH3 peptides of pro-apoptotic Bcl-2 family proteins in vitro, consistent with a role for N1L in modulating host antiviral defenses.
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{{ABSTRACT_PUBMED_17123957}}
==About this Structure==
==About this Structure==
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[[Category: Stec, B.]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 07:01:06 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 19:25:26 2008''

Revision as of 16:25, 27 July 2008

Image:2i39.png

Template:STRUCTURE 2i39

Crystal structure of Vaccinia virus N1L protein

Template:ABSTRACT PUBMED 17123957

About this Structure

2I39 is a Single protein structure of sequence from Vaccinia virus. Full crystallographic information is available from OCA.

Reference

Vaccinia virus N1L protein resembles a B cell lymphoma-2 (Bcl-2) family protein., Aoyagi M, Zhai D, Jin C, Aleshin AE, Stec B, Reed JC, Liddington RC, Protein Sci. 2007 Jan;16(1):118-24. Epub 2006 Nov 22. PMID:17123957

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