2i3r

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{{STRUCTURE_2i3r| PDB=2i3r | SCENE= }}
{{STRUCTURE_2i3r| PDB=2i3r | SCENE= }}
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'''Engineered catalytic domain of protein tyrosine phosphatase HPTPbeta'''
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===Engineered catalytic domain of protein tyrosine phosphatase HPTPbeta===
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==Overview==
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Protein tyrosine phosphatases (PTPs) play roles in many biological processes and are considered to be important targets for drug discovery. As inhibitor development has proven challenging, crystal structure-based design will be very helpful to advance inhibitor potency and selectivity. Successful application of protein crystallography to drug discovery heavily relies on high-quality crystal structures of the protein of interest complexed with pharmaceutically interesting ligands. It is very important to be able to produce protein-ligand crystals rapidly and reproducibly for as many ligands as necessary. This study details our efforts to engineer the catalytic domain of human protein tyrosine phosphatase beta (HPTPbeta-CD) with properties suitable for rapid-turnaround crystallography. Structures of apo HPTPbeta-CD and its complexes with several novel small-molecule inhibitors are presented here for the first time.
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(as it appears on PubMed at http://www.pubmed.gov), where 17139078 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17139078}}
==About this Structure==
==About this Structure==
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[[Category: Sulfamic acid]]
[[Category: Sulfamic acid]]
[[Category: Wpd-loop]]
[[Category: Wpd-loop]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 07:01:57 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 16:20:11 2008''

Revision as of 13:20, 28 July 2008

Image:2i3r.png

Template:STRUCTURE 2i3r

Engineered catalytic domain of protein tyrosine phosphatase HPTPbeta

Template:ABSTRACT PUBMED 17139078

About this Structure

2I3R is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Engineering the catalytic domain of human protein tyrosine phosphatase beta for structure-based drug discovery., Evdokimov AG, Pokross M, Walter R, Mekel M, Cox B, Li C, Bechard R, Genbauffe F, Andrews R, Diven C, Howard B, Rastogi V, Gray J, Maier M, Peters KG, Acta Crystallogr D Biol Crystallogr. 2006 Dec;62(Pt 12):1435-45. Epub 2006, Nov 23. PMID:17139078

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