2i47

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[[Image:2i47.gif|left|200px]]
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{{STRUCTURE_2i47| PDB=2i47 | SCENE= }}
{{STRUCTURE_2i47| PDB=2i47 | SCENE= }}
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'''Crystal structure of catalytic domain of TACE with inhibitor'''
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===Crystal structure of catalytic domain of TACE with inhibitor===
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==Overview==
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By focusing on the P1 portion of the piperidine beta-sulfone ligands we identified a motif that induces selectivity and resulted in a series of TACE inhibitors that demonstrated excellent in vitro potency against isolated TACE enzyme and excellent selectivity over MMPs 1, 2, 9, 13, and 14.
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(as it appears on PubMed at http://www.pubmed.gov), where 17064892 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17064892}}
==About this Structure==
==About this Structure==
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[[Category: Tace-inhibitor complex]]
[[Category: Tace-inhibitor complex]]
[[Category: Tace/adam-17]]
[[Category: Tace/adam-17]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 07:02:50 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 11:17:29 2008''

Revision as of 08:17, 28 July 2008

Template:STRUCTURE 2i47

Crystal structure of catalytic domain of TACE with inhibitor

Template:ABSTRACT PUBMED 17064892

About this Structure

2I47 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Identification of potent and selective TACE inhibitors via the S1 pocket., Condon JS, Joseph-McCarthy D, Levin JI, Lombart HG, Lovering FE, Sun L, Wang W, Xu W, Zhang Y, Bioorg Med Chem Lett. 2007 Jan 1;17(1):34-9. Epub 2006 Oct 5. PMID:17064892

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