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2i53

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{{STRUCTURE_2i53| PDB=2i53 | SCENE= }}
{{STRUCTURE_2i53| PDB=2i53 | SCENE= }}
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'''Crystal structure of Cyclin K'''
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===Crystal structure of Cyclin K===
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==Overview==
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Cyclin K and the closely related cyclins T1, T2a, and T2b interact with cyclin-dependent kinase 9 (CDK9) forming multiple nuclear complexes, referred to collectively as positive transcription elongation factor b (P-TEFb). Through phosphorylation of the C-terminal domain of the RNA polymerase II largest subunit, distinct P-TEFb species regulate the transcriptional elongation of specific genes that play central roles in human physiology and disease development, including cardiac hypertrophy and human immunodeficiency virus-1 pathogenesis. We have determined the crystal structure of human cyclin K (residues 11-267) at 1.5 A resolution, which represents the first atomic structure of a P-TEFb subunit. The cyclin K fold comprises two typical cyclin boxes with two short helices preceding the N-terminal box. A prominent feature of cyclin K is an additional helix (H4a) in the first cyclin box that obstructs the binding pocket for the cell-cycle inhibitor p27(Kip1). Modeling of CDK9 bound to cyclin K provides insights into the structural determinants underlying the formation and regulation of this complex. A homology model of human cyclin T1 generated using the cyclin K structure as a template reveals that the two proteins have similar structures, as expected from their high level of sequence identity. Nevertheless, their CDK9-interacting surfaces display significant structural differences, which could potentially be exploited for the design of cyclin-targeted inhibitors of the CDK9-cyclin K and CDK9-cyclin T1 complexes.
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(as it appears on PubMed at http://www.pubmed.gov), where 17169370 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17169370}}
==About this Structure==
==About this Structure==
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[[Category: Positive transcription elongation factor]]
[[Category: Positive transcription elongation factor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 07:04:44 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 05:43:34 2008''

Revision as of 02:43, 28 July 2008

Image:2i53.png

Template:STRUCTURE 2i53

Crystal structure of Cyclin K

Template:ABSTRACT PUBMED 17169370

About this Structure

2I53 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of human cyclin K, a positive regulator of cyclin-dependent kinase 9., Baek K, Brown RS, Birrane G, Ladias JA, J Mol Biol. 2007 Feb 16;366(2):563-73. Epub 2006 Nov 18. PMID:17169370

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