2i5w

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:2i5w.gif|left|200px]]
+
{{Seed}}
 +
[[Image:2i5w.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_2i5w| PDB=2i5w | SCENE= }}
{{STRUCTURE_2i5w| PDB=2i5w | SCENE= }}
-
'''Structure of hOGG1 crosslinked to DNA sampling a normal G adjacent to an oxoG'''
+
===Structure of hOGG1 crosslinked to DNA sampling a normal G adjacent to an oxoG===
-
==Overview==
+
<!--
-
How DNA glycosylases search through millions of base pairs and discriminate between rare sites of damage and otherwise undamaged bases is poorly understood. Even less understood are the details of the structural states arising from DNA glycosylases interacting with undamaged DNA. Recognizing the mutagenic lesion 7,8-dihydro-8-oxoguanine (8-oxoguanine, oxoG) represents an especially formidable challenge, because this oxidized nucleobase differs by only two atoms from its normal counterpart, guanine (G), and buried in the structure of naked B-form DNA, oxoG and G are practically indistinguishable from each other. We have used disulfide cross-linking technology to capture a human oxoG repair protein, 8-oxoguanine DNA glycosylase I (hOGG1) sampling an undamaged G:C base pair located adjacent to an oxoG:C base pair in DNA. The x-ray structure of the trapped complex reveals that the presence of the 8-oxoG drastically changes the local conformation of the extruded G. The extruded but intrahelical state of the G in this structure offers a view of an early intermediate in the base-extrusion pathway.
+
The line below this paragraph, {{ABSTRACT_PUBMED_17015827}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 17015827 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_17015827}}
==About this Structure==
==About this Structure==
Line 27: Line 31:
[[Category: Dna glycosylase]]
[[Category: Dna glycosylase]]
[[Category: Protein-dna complex]]
[[Category: Protein-dna complex]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 07:06:52 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 19:03:14 2008''

Revision as of 16:03, 28 July 2008

Image:2i5w.png

Template:STRUCTURE 2i5w

Structure of hOGG1 crosslinked to DNA sampling a normal G adjacent to an oxoG

Template:ABSTRACT PUBMED 17015827

About this Structure

2I5W is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

A nucleobase lesion remodels the interaction of its normal neighbor in a DNA glycosylase complex., Banerjee A, Verdine GL, Proc Natl Acad Sci U S A. 2006 Oct 10;103(41):15020-5. Epub 2006 Oct 2. PMID:17015827

Page seeded by OCA on Mon Jul 28 19:03:14 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2i5w"
Personal tools