2i5x

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:2i5x.gif|left|200px]]
+
{{Seed}}
 +
[[Image:2i5x.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_2i5x| PDB=2i5x | SCENE= }}
{{STRUCTURE_2i5x| PDB=2i5x | SCENE= }}
-
'''Engineering the PTPbeta catalytic domain with improved crystallization properties'''
+
===Engineering the PTPbeta catalytic domain with improved crystallization properties===
-
==Overview==
+
<!--
-
Protein tyrosine phosphatases (PTPs) play roles in many biological processes and are considered to be important targets for drug discovery. As inhibitor development has proven challenging, crystal structure-based design will be very helpful to advance inhibitor potency and selectivity. Successful application of protein crystallography to drug discovery heavily relies on high-quality crystal structures of the protein of interest complexed with pharmaceutically interesting ligands. It is very important to be able to produce protein-ligand crystals rapidly and reproducibly for as many ligands as necessary. This study details our efforts to engineer the catalytic domain of human protein tyrosine phosphatase beta (HPTPbeta-CD) with properties suitable for rapid-turnaround crystallography. Structures of apo HPTPbeta-CD and its complexes with several novel small-molecule inhibitors are presented here for the first time.
+
The line below this paragraph, {{ABSTRACT_PUBMED_17139078}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 17139078 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_17139078}}
==About this Structure==
==About this Structure==
Line 32: Line 36:
[[Category: Protein tyrosine phosphatase]]
[[Category: Protein tyrosine phosphatase]]
[[Category: Wpd-loop]]
[[Category: Wpd-loop]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 07:07:00 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 00:37:15 2008''

Revision as of 21:37, 27 July 2008

Image:2i5x.png

Template:STRUCTURE 2i5x

Engineering the PTPbeta catalytic domain with improved crystallization properties

Template:ABSTRACT PUBMED 17139078

About this Structure

2I5X is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Engineering the catalytic domain of human protein tyrosine phosphatase beta for structure-based drug discovery., Evdokimov AG, Pokross M, Walter R, Mekel M, Cox B, Li C, Bechard R, Genbauffe F, Andrews R, Diven C, Howard B, Rastogi V, Gray J, Maier M, Peters KG, Acta Crystallogr D Biol Crystallogr. 2006 Dec;62(Pt 12):1435-45. Epub 2006, Nov 23. PMID:17139078

Page seeded by OCA on Mon Jul 28 00:37:15 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2i5x"
Personal tools