2i6t
From Proteopedia
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{{STRUCTURE_2i6t| PDB=2i6t | SCENE= }} | {{STRUCTURE_2i6t| PDB=2i6t | SCENE= }} | ||
| - | + | ===Orthorhombic Structure of the LDH domain of Human Ubiquitin-conjugating Enzyme E2-like Isoform A=== | |
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| - | ==Overview== | ||
| - | Recent studies have shown that ubiquitination is an essential factor in endosomal sorting and virus assembly. The human TSG101 gene has been demonstrated to belong to a group of genes coding for apparently inactive E2 ubiquitin-conjugating enzymes, which exert regulatory effects on E2 activity in cellular ubiquitination processes. In this study, a novel human cDNA (UEV3) encoding a putative protein of 379 amino acids was isolated from a human placenta library that may represent a partial paralogue of human TSG101. The predicted protein contains an N-terminal domain homologous to the catalytic domain of ubiquitin-conjugating enzymes (Ubc), which is fused to a sequence showing significant homology to members of the lactate dehydrogenase protein family. The UEV3 gene is located on chromosome 11 closely adjacent to TSG101 and LDH-C. Northern blot and UEV3-specific reverse transcription/polymerase chain reaction (RT/PCR) analyses of various colon carcinoma cell lines as well as both normal and tumor samples from colon revealed an expression of the UEV3 cDNA in all tested samples. | ||
==About this Structure== | ==About this Structure== | ||
| - | 2I6T is a | + | 2I6T is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I6T OCA]. |
==Reference== | ==Reference== | ||
| - | + | <ref group="xtra">PMID:12427560</ref><references group="xtra"/> | |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Single protein]] | ||
[[Category: Arrowsmith, C H.]] | [[Category: Arrowsmith, C H.]] | ||
[[Category: Avvakumov, G V.]] | [[Category: Avvakumov, G V.]] | ||
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[[Category: Oxidoreductase]] | [[Category: Oxidoreductase]] | ||
[[Category: Ubiquitin-protein ligase]] | [[Category: Ubiquitin-protein ligase]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
| + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 12:39:22 2009'' | ||
Revision as of 10:39, 16 February 2009
Orthorhombic Structure of the LDH domain of Human Ubiquitin-conjugating Enzyme E2-like Isoform A
About this Structure
2I6T is a 2 chains structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Kloor M, Bork P, Duwe A, Klaes R, von Knebel Doeberitz M, Ridder R. Identification and characterization of UEV3, a human cDNA with similarities to inactive E2 ubiquitin-conjugating enzymes. Biochim Biophys Acta. 2002 Dec 12;1579(2-3):219-24. PMID:12427560
Page seeded by OCA on Mon Feb 16 12:39:22 2009
Categories: Homo sapiens | Arrowsmith, C H. | Avvakumov, G V. | Bochkarev, A. | Butler-Cole, C. | Dhe-Paganon, S. | Edwards, A M. | Jr., P J.Finerty. | Newman, E M. | Sundstrom, M. | Tempel, W. | Walker, J R. | Weigelt, J. | Xue, S. | L-lactate dehydrogenase | Oxidoreductase | Ubiquitin-protein ligase
