2i9a

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{{STRUCTURE_2i9a| PDB=2i9a | SCENE= }}
{{STRUCTURE_2i9a| PDB=2i9a | SCENE= }}
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'''Crystal structure of the free aminoterminal fragment of urokinase type plasminogen activator (ATF)'''
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===Crystal structure of the free aminoterminal fragment of urokinase type plasminogen activator (ATF)===
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==Overview==
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Recent studies indicate that binding of the urokinase-type plasminogen activator (uPA) to its high-affinity receptor (uPAR) orchestrates uPAR interactions with other cellular components that play a pivotal role in diverse (patho-)physiological processes, including wound healing, angiogenesis, inflammation, and cancer metastasis. However, notwithstanding the wealth of biochemical data available describing the activities of uPAR, little is known about the exact mode of uPAR/uPA interactions or the presumed conformational changes that accompany uPA/uPAR engagement. Here, we report the crystal structure of soluble urokinase plasminogen activator receptor (suPAR), which contains the three domains of the wild-type receptor but lacks the cell-surface anchoring sequence, in complex with the amino-terminal fragment of urokinase-type plasminogen activator (ATF), at the resolution of 2.8 A. We report the 1.9 A crystal structure of free ATF. Our results provide a structural basis, represented by conformational changes induced in uPAR, for several published biochemical observations describing the nature of uPAR/uPA interactions and provide insight into mechanisms that may be responsible for the cellular responses induced by uPA binding.
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The line below this paragraph, {{ABSTRACT_PUBMED_16979660}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 16979660 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16979660}}
==Disease==
==Disease==
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[[Category: Growth factor-like domain]]
[[Category: Growth factor-like domain]]
[[Category: Kringle domain]]
[[Category: Kringle domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 07:13:04 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 00:48:37 2008''

Revision as of 21:48, 27 July 2008

Image:2i9a.png

Template:STRUCTURE 2i9a

Contents

Crystal structure of the free aminoterminal fragment of urokinase type plasminogen activator (ATF)

Template:ABSTRACT PUBMED 16979660

Disease

Known disease associated with this structure: Alzheimer disease, late-onset, susceptibility to OMIM:[191840]

About this Structure

2I9A is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural basis of interaction between urokinase-type plasminogen activator and its receptor., Barinka C, Parry G, Callahan J, Shaw DE, Kuo A, Bdeir K, Cines DB, Mazar A, Lubkowski J, J Mol Biol. 2006 Oct 20;363(2):482-95. Epub 2006 Aug 26. PMID:16979660

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