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2i9s

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[[Image:2i9s.jpg|left|200px]]
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{{STRUCTURE_2i9s| PDB=2i9s | SCENE= }}
{{STRUCTURE_2i9s| PDB=2i9s | SCENE= }}
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'''The solution structure of the core of mesoderm development (MESD).'''
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===The solution structure of the core of mesoderm development (MESD).===
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==Overview==
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Mesoderm development (MESD) is a 224 amino acid mouse protein that acts as a molecular chaperone for receptors of the low-density lipoprotein receptor (LDLR) family. By recording (15)N-HSQC-NMR spectra of six different MESD constructs, we could determine a highly structured core region corresponding to residues 104-177. Here we firstly present the solution structure of this highly conserved core of MESD. It shows a four-stranded anti-parallel beta-sheet and two alpha-helices situated on one side of the sheet. Although described in the literature as structurally homologues to ferredoxins, the connectivity of secondary structure elements is different in the MESD fold. A structural comparison to entries of the PDB reveals a frequent domain with low sequence homology annotated as HMA and P-II domains in Pfam.
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(as it appears on PubMed at http://www.pubmed.gov), where 17342452 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17342452}}
==About this Structure==
==About this Structure==
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2I9S is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I9S OCA].
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2I9S is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I9S OCA].
==Reference==
==Reference==
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[[Category: Schmieder, P.]]
[[Category: Schmieder, P.]]
[[Category: Ferredoxin-like-fold]]
[[Category: Ferredoxin-like-fold]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 07:14:04 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 03:01:40 2008''

Revision as of 00:01, 29 July 2008

Image:2i9s.png

Template:STRUCTURE 2i9s

The solution structure of the core of mesoderm development (MESD).

Template:ABSTRACT PUBMED 17342452

About this Structure

2I9S is a Single protein structure of sequence from Mus musculus. Full experimental information is available from OCA.

Reference

The solution structure of the core of mesoderm development (MESD), a chaperone for members of the LDLR-family., Kohler C, Andersen OM, Diehl A, Krause G, Schmieder P, Oschkinat H, J Struct Funct Genomics. 2006 Dec;7(3-4):131-8. Epub 2007 Mar 7. PMID:17342452

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