2iad

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[[Image:2iad.gif|left|200px]]
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{{STRUCTURE_2iad| PDB=2iad | SCENE= }}
{{STRUCTURE_2iad| PDB=2iad | SCENE= }}
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'''CLASS II MHC I-AD IN COMPLEX WITH AN INFLUENZA HEMAGGLUTININ PEPTIDE 126-138'''
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===CLASS II MHC I-AD IN COMPLEX WITH AN INFLUENZA HEMAGGLUTININ PEPTIDE 126-138===
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==Overview==
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We have determined the structures of I-Ad covalently linked to an ovalbumin peptide (OVA323-339) and to an influenza virus hemagglutinin peptide (HA126-138). The floor of the peptide-binding groove contains an unusual beta bulge, not seen in I-E and DR structures, that affects numerous interactions between the alpha and beta chains and bound peptide. Unlike other MHC-peptide complexes, the peptides do not insert any large anchor residues into the binding pockets of the shallow I-Ad binding groove. The previously identified six-residue "core" binding motif of I-Ad occupies only the P4 to P9 pockets, implying that specificity of T cell receptor recognition of I-Ad-peptide complexes can be accomplished by peptides that only partially fill the MHC groove.
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The line below this paragraph, {{ABSTRACT_PUBMED_9529149}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 9529149 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9529149}}
==About this Structure==
==About this Structure==
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[[Category: Class ii mhc i-ad]]
[[Category: Class ii mhc i-ad]]
[[Category: Mhc ii]]
[[Category: Mhc ii]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 07:15:21 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 11:33:52 2008''

Revision as of 08:33, 28 July 2008

Image:2iad.png

Template:STRUCTURE 2iad

CLASS II MHC I-AD IN COMPLEX WITH AN INFLUENZA HEMAGGLUTININ PEPTIDE 126-138

Template:ABSTRACT PUBMED 9529149

About this Structure

2IAD is a Protein complex structure of sequences from Mus musculus. Full crystallographic information is available from OCA.

Reference

Crystal structures of two I-Ad-peptide complexes reveal that high affinity can be achieved without large anchor residues., Scott CA, Peterson PA, Teyton L, Wilson IA, Immunity. 1998 Mar;8(3):319-29. PMID:9529149

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