2icj

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:2icj.jpg|left|200px]]
+
{{Seed}}
 +
[[Image:2icj.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_2icj| PDB=2icj | SCENE= }}
{{STRUCTURE_2icj| PDB=2icj | SCENE= }}
-
'''The crystal structure of human isopentenyl diphophate isomerase'''
+
===The crystal structure of human isopentenyl diphophate isomerase===
-
==Overview==
+
<!--
-
Isopentenyl diphosphate isomerase catalyses a crucial activation step in the biosynthesis of isoprenoids, one of the most ancient and diverse classes of natural products. This enzyme is responsible for an unusual isomerization of the inactive carbon-carbon double bond of isopentenyl diphosphate (IPP) to create its electrophilic allylic isomer dimethylallyl diphosphate (DMAPP). Here we report the crystal structure of human IPP isomerase at 1.7 A resolution and the complex structure with its native substrate at 1.9 A resolution. These structures reveal a mechanism wherein interconversion is catalyzed by a stereoselective antarafacial [1.3] transposition of a proton involving the indispensable residues Cys87, Glu149, Trp197 and Tyr137. A newly identified alternative conformation of Cys87 driven by Trp197 and the selectivity of different metal ions located in the active site provide further insight into the catalytic mechanism. Comparison with Escherichia coli IPP isomerase reveals a novel substrate entrance in human IPP isomerase.
+
The line below this paragraph, {{ABSTRACT_PUBMED_17250851}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 17250851 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_17250851}}
==About this Structure==
==About this Structure==
Line 28: Line 32:
[[Category: Crystal structure]]
[[Category: Crystal structure]]
[[Category: Human isopentenyl diphophate isomerase]]
[[Category: Human isopentenyl diphophate isomerase]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 07:20:02 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 03:35:22 2008''

Revision as of 00:35, 29 July 2008

Image:2icj.png

Template:STRUCTURE 2icj

The crystal structure of human isopentenyl diphophate isomerase

Template:ABSTRACT PUBMED 17250851

About this Structure

2ICJ is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The crystal structure of human isopentenyl diphosphate isomerase at 1.7 A resolution reveals its catalytic mechanism in isoprenoid biosynthesis., Zheng W, Sun F, Bartlam M, Li X, Li R, Rao Z, J Mol Biol. 2007 Mar 9;366(5):1447-58. Epub 2006 Dec 24. PMID:17250851

Page seeded by OCA on Tue Jul 29 03:35:22 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2icj"
Personal tools