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2icw

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{{STRUCTURE_2icw| PDB=2icw | SCENE= }}
{{STRUCTURE_2icw| PDB=2icw | SCENE= }}
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'''Crystal structure of a complete ternary complex between TCR, superantigen, and peptide-MHC class II molecule'''
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===Crystal structure of a complete ternary complex between TCR, superantigen, and peptide-MHC class II molecule===
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==Overview==
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'Superantigens' (SAgs) trigger the massive activation of T cells by simultaneous interactions with MHC and TCR receptors, leading to human diseases. Here we present the first crystal structure, at 2.5-A resolution, of a complete ternary complex between a SAg and its two receptors, HLA-DR1/HA and TCR. The most striking finding is that the SAg Mycoplasma arthritidis mitogen, unlike others, has direct contacts not only with TCR Vbeta but with TCR Valpha.
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(as it appears on PubMed at http://www.pubmed.gov), where 17220897 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17220897}}
==About this Structure==
==About this Structure==
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[[Category: Superantigen]]
[[Category: Superantigen]]
[[Category: Tcr]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 07:20:38 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 11:43:08 2008''

Revision as of 08:43, 29 July 2008

Image:2icw.png

Template:STRUCTURE 2icw

Crystal structure of a complete ternary complex between TCR, superantigen, and peptide-MHC class II molecule

Template:ABSTRACT PUBMED 17220897

About this Structure

2ICW is a Protein complex structure of sequences from Homo sapiens, Mus musculus and Mycoplasma arthritidis. Full crystallographic information is available from OCA.

Reference

Crystal structure of a complete ternary complex of TCR, superantigen and peptide-MHC., Wang L, Zhao Y, Li Z, Guo Y, Jones LL, Kranz DM, Mourad W, Li H, Nat Struct Mol Biol. 2007 Feb;14(2):169-71. Epub 2007 Jan 14. PMID:17220897

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