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2ido

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{{STRUCTURE_2ido| PDB=2ido | SCENE= }}
{{STRUCTURE_2ido| PDB=2ido | SCENE= }}
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'''Structure of the E. coli Pol III epsilon-Hot proofreading complex'''
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===Structure of the E. coli Pol III epsilon-Hot proofreading complex===
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==Overview==
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The epsilon subunit of Escherichia coli DNA polymerase III possesses 3'-exonucleolytic proofreading activity. Within the Pol III core, epsilon is tightly bound between the alpha subunit (DNA polymerase) and subunit. Here, we present the crystal structure of epsilon in complex with HOT, the bacteriophage P1-encoded homolog of , at 2.1 A resolution. The epsilon-HOT interface is defined by two areas of contact: an interaction of the previously unstructured N terminus of HOT with an edge of the epsilon central beta-sheet as well as interactions between HOT and the catalytically important helix alpha1-loop-helix alpha2 motif of epsilon. This structure provides insight into how HOT and, by implication, may stabilize the epsilon subunit, thus promoting efficient proofreading during chromosomal replication.
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(as it appears on PubMed at http://www.pubmed.gov), where 16973612 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16973612}}
==About this Structure==
==About this Structure==
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[[Category: Pol iii]]
[[Category: Pol iii]]
[[Category: Polymerase]]
[[Category: Polymerase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 07:22:44 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 17:26:12 2008''

Revision as of 14:26, 28 July 2008

Image:2ido.png

Template:STRUCTURE 2ido

Structure of the E. coli Pol III epsilon-Hot proofreading complex

Template:ABSTRACT PUBMED 16973612

About this Structure

2IDO is a Protein complex structure of sequences from Enterobacteria phage p1 and Escherichia coli. Full crystallographic information is available from OCA.

Reference

Structure of the Escherichia coli DNA polymerase III epsilon-HOT proofreading complex., Kirby TW, Harvey S, DeRose EF, Chalov S, Chikova AK, Perrino FW, Schaaper RM, London RE, Pedersen LC, J Biol Chem. 2006 Dec 15;281(50):38466-71. Epub 2006 Sep 13. PMID:16973612

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