2if1

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[[Image:2if1.jpg|left|200px]]
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{{STRUCTURE_2if1| PDB=2if1 | SCENE= }}
{{STRUCTURE_2if1| PDB=2if1 | SCENE= }}
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'''HUMAN TRANSLATION INITIATION FACTOR EIF1, NMR, 29 STRUCTURES'''
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===HUMAN TRANSLATION INITIATION FACTOR EIF1, NMR, 29 STRUCTURES===
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==Overview==
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eIF1 is a universally conserved translation factor that is necessary for scanning and involved in initiation site selection. We have determined the solution structure of human eIF1 with an N-terminal His tag using NMR spectroscopy. Residues 29-113 of the native sequence form a tightly packed domain with two alpha-helices on one side of a five-stranded parallel and antiparallel beta-sheet. The fold is new but similar to that of several ribosomal proteins and RNA-binding domains. A likely binding site is indicated by yeast mutations and conserved residues located together on the surface. No interaction with recombinant eIF5 or the initiation site RNA GCCACAAUGGCA was detected by NMR, but GST pull-down experiments show that eIF1 binds specifically to the p110 subunit of eIF3. This interaction explains how eIF1 is recruited to the 40S ribosomal subunit.
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{{ABSTRACT_PUBMED_10228174}}
==About this Structure==
==About this Structure==
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2IF1 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IF1 OCA].
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2IF1 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IF1 OCA].
==Reference==
==Reference==
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[[Category: Wagner, G.]]
[[Category: Wagner, G.]]
[[Category: Translation initiation factor]]
[[Category: Translation initiation factor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 07:25:46 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 15:26:37 2008''

Revision as of 12:26, 29 July 2008

Image:2if1.png

Template:STRUCTURE 2if1

HUMAN TRANSLATION INITIATION FACTOR EIF1, NMR, 29 STRUCTURES

Template:ABSTRACT PUBMED 10228174

About this Structure

2IF1 is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

Structure and interactions of the translation initiation factor eIF1., Fletcher CM, Pestova TV, Hellen CU, Wagner G, EMBO J. 1999 May 4;18(9):2631-7. PMID:10228174

Page seeded by OCA on Tue Jul 29 15:26:37 2008

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