2ih3

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[[Image:2ih3.gif|left|200px]]
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{{STRUCTURE_2ih3| PDB=2ih3 | SCENE= }}
{{STRUCTURE_2ih3| PDB=2ih3 | SCENE= }}
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'''Ion selectivity in a semi-synthetic K+ channel locked in the conductive conformation'''
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===Ion selectivity in a semi-synthetic K+ channel locked in the conductive conformation===
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==Overview==
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Potassium channels are K+-selective protein pores in cell membrane. The selectivity filter is the functional unit that allows K+ channels to distinguish potassium (K+) and sodium (Na+) ions. The filter's structure depends on whether K+ or Na+ ions are bound inside it. We synthesized a K+ channel containing the d-enantiomer of alanine in place of a conserved glycine and found by x-ray crystallography that its filter maintains the K+ (conductive) structure in the presence of Na+ and very low concentrations of K+. This channel conducts Na+ in the absence of K+ but not in the presence of K+. These findings demonstrate that the ability of the channel to adapt its structure differently to K+ and Na+ is a fundamental aspect of ion selectivity, as is the ability of multiple K+ ions to compete effectively with Na+ for the conductive filter.
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(as it appears on PubMed at http://www.pubmed.gov), where 17095703 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17095703}}
==About this Structure==
==About this Structure==
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[[Category: Valiyaveetil, F I.]]
[[Category: Valiyaveetil, F I.]]
[[Category: Ion channel d-amino acid semi-synthetic]]
[[Category: Ion channel d-amino acid semi-synthetic]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 07:29:45 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 21:29:35 2008''

Revision as of 18:29, 27 July 2008

Image:2ih3.png

Template:STRUCTURE 2ih3

Ion selectivity in a semi-synthetic K+ channel locked in the conductive conformation

Template:ABSTRACT PUBMED 17095703

About this Structure

2IH3 is a Single protein structure of sequence from Mus musculus and Streptomyces lividans. Full crystallographic information is available from OCA.

Reference

Ion selectivity in a semisynthetic K+ channel locked in the conductive conformation., Valiyaveetil FI, Leonetti M, Muir TW, Mackinnon R, Science. 2006 Nov 10;314(5801):1004-7. PMID:17095703

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