2iny

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{{STRUCTURE_2iny| PDB=2iny | SCENE= }}
{{STRUCTURE_2iny| PDB=2iny | SCENE= }}
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'''Nanoporous Crystals of Chicken Embryo Lethal Orphan (CELO) Adenovirus Major Coat Protein, Hexon'''
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===Nanoporous Crystals of Chicken Embryo Lethal Orphan (CELO) Adenovirus Major Coat Protein, Hexon===
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==Overview==
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CELO (chicken embryo lethal orphan) virus is an avian adenovirus that is being developed as a gene transfer vector. Its trimeric major coat protein (942 residues, 106,709 Da) has 42% sequence identity to human adenovirus type 2 (AdH2) hexon and 45% to AdH5 hexon. For structural studies, the growth of CELO virus has been optimized, and its hexon purified and crystallized. The hexon crystals, the first non-human example, diffract to 3.9 A resolution. Molecular replacement using the AdH5 model was used to identify the location of the CELO hexon within the unit cell. There is one hexon monomer in the asymmetric unit of the trigonal space group P321 (a=b=157.8 A, c=114.2 A, gamma=120 degrees) and the solvent content is 67.8%. The hexons pack in a hexagonal honeycomb so that large approximately 100 A diameter channels run through the entire crystal. This remarkable property of the crystals lends itself to their exploitation as a nanomaterial. Structural studies on CELO will elucidate the differences between avian and human adenoviruses and contribute to a better understanding of adenoviruses with non-human hosts.
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(as it appears on PubMed at http://www.pubmed.gov), where 17071105 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17071105}}
==About this Structure==
==About this Structure==
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[[Category: Nanotechnology]]
[[Category: Nanotechnology]]
[[Category: Viral jelly roll]]
[[Category: Viral jelly roll]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 07:42:07 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 09:45:20 2008''

Revision as of 06:45, 29 July 2008

Image:2iny.png

Template:STRUCTURE 2iny

Nanoporous Crystals of Chicken Embryo Lethal Orphan (CELO) Adenovirus Major Coat Protein, Hexon

Template:ABSTRACT PUBMED 17071105

About this Structure

2INY is a Single protein structure of sequence from Fowl adenovirus 1. Full crystallographic information is available from OCA.

Reference

Nanoporous crystals of chicken embryo lethal orphan (CELO) adenovirus major coat protein, hexon., Xu L, Benson SD, Burnett RM, J Struct Biol. 2007 Feb;157(2):424-31. Epub 2006 Sep 14. PMID:17071105

Page seeded by OCA on Tue Jul 29 09:45:20 2008

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