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2iqh

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{{STRUCTURE_2iqh| PDB=2iqh | SCENE= }}
{{STRUCTURE_2iqh| PDB=2iqh | SCENE= }}
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'''Influenza A virus nucleoprotein NP at 3.2A resolution'''
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===Influenza A virus nucleoprotein NP at 3.2A resolution===
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==Overview==
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Influenza A viruses pose a serious threat to world public health, particularly the currently circulating avian H5N1 viruses. The influenza viral nucleoprotein forms the protein scaffold of the helical genomic ribonucleoprotein complexes, and has a critical role in viral RNA replication. Here we report a 3.2 A crystal structure of this nucleoprotein, the overall shape of which resembles a crescent with a head and a body domain, with a protein fold different compared with that of the rhabdovirus nucleoprotein. Oligomerization of the influenza virus nucleoprotein is mediated by a flexible tail loop that is inserted inside a neighbouring molecule. This flexibility in the tail loop enables the nucleoprotein to form loose polymers as well as rigid helices, both of which are important for nucleoprotein functions. Single residue mutations in the tail loop result in the complete loss of nucleoprotein oligomerization. An RNA-binding groove, which is found between the head and body domains at the exterior of the nucleoprotein oligomer, is lined with highly conserved basic residues widely distributed in the primary sequence. The nucleoprotein structure shows that only one of two proposed nuclear localization signals are accessible, and suggests that the body domain of nucleoprotein contains the binding site for the viral polymerase. Our results identify the tail loop binding pocket as a potential target for antiviral development.
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(as it appears on PubMed at http://www.pubmed.gov), where 17151603 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17151603}}
==About this Structure==
==About this Structure==
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[[Category: Polymerase binding]]
[[Category: Polymerase binding]]
[[Category: Rna binding]]
[[Category: Rna binding]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 07:46:32 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 20:09:29 2008''

Revision as of 17:09, 28 July 2008

Image:2iqh.png

Template:STRUCTURE 2iqh

Influenza A virus nucleoprotein NP at 3.2A resolution

Template:ABSTRACT PUBMED 17151603

About this Structure

2IQH is a Single protein structure of sequence from Influenza a virus. Full crystallographic information is available from OCA.

Reference

The mechanism by which influenza A virus nucleoprotein forms oligomers and binds RNA., Ye Q, Krug RM, Tao YJ, Nature. 2006 Dec 21;444(7122):1078-82. Epub 2006 Dec 6. PMID:17151603

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