2irz

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:2irz.gif|left|200px]]
+
{{Seed}}
 +
[[Image:2irz.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_2irz| PDB=2irz | SCENE= }}
{{STRUCTURE_2irz| PDB=2irz | SCENE= }}
-
'''Crystal structure of human Beta-secretase complexed with inhibitor'''
+
===Crystal structure of human Beta-secretase complexed with inhibitor===
-
==Overview==
+
<!--
-
We describe the discovery and optimization of tertiary carbinamine derived inhibitors of the enzyme beta-secretase (BACE-1). These novel non-transition-state-derived ligands incorporate a single primary amine to interact with the catalytic aspartates of the target enzyme. Optimization of this series provided inhibitors with intrinsic and functional potency comparable to evolved transition state isostere derived inhibitors of BACE-1.
+
The line below this paragraph, {{ABSTRACT_PUBMED_17149856}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 17149856 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_17149856}}
==About this Structure==
==About this Structure==
Line 26: Line 30:
[[Category: Aspartyl protease]]
[[Category: Aspartyl protease]]
[[Category: Hydrolase]]
[[Category: Hydrolase]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 07:47:51 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 19:44:58 2008''

Revision as of 16:45, 28 July 2008

Image:2irz.png

Template:STRUCTURE 2irz

Crystal structure of human Beta-secretase complexed with inhibitor

Template:ABSTRACT PUBMED 17149856

About this Structure

2IRZ is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Discovery of oxadiazoyl tertiary carbinamine inhibitors of beta-secretase (BACE-1)., Rajapakse HA, Nantermet PG, Selnick HG, Munshi S, McGaughey GB, Lindsley SR, Young MB, Lai MT, Espeseth AS, Shi XP, Colussi D, Pietrak B, Crouthamel MC, Tugusheva K, Huang Q, Xu M, Simon AJ, Kuo L, Hazuda DJ, Graham S, Vacca JP, J Med Chem. 2006 Dec 14;49(25):7270-3. PMID:17149856

Page seeded by OCA on Mon Jul 28 19:44:58 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2irz"
Personal tools