2ius

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{{STRUCTURE_2ius| PDB=2ius | SCENE= }}
{{STRUCTURE_2ius| PDB=2ius | SCENE= }}
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'''E. COLI FTSK MOTOR DOMAIN'''
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===E. COLI FTSK MOTOR DOMAIN===
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==Overview==
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FtsK is a DNA translocase that coordinates chromosome segregation and cell division in bacteria. In addition to its role as activator of XerCD site-specific recombination, FtsK can translocate double-stranded DNA (dsDNA) rapidly and directionally and reverse direction. We present crystal structures of the FtsK motor domain monomer, showing that it has a RecA-like core, the FtsK hexamer, and also showing that it is a ring with a large central annulus and a dodecamer consisting of two hexamers, head to head. Electron microscopy (EM) demonstrates the DNA-dependent existence of hexamers in solution and shows that duplex DNA passes through the middle of each ring. Comparison of FtsK monomer structures from two different crystal forms highlights a conformational change that we propose is the structural basis for a rotary inchworm mechanism of DNA translocation.
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{{ABSTRACT_PUBMED_16916635}}
==About this Structure==
==About this Structure==
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[[Category: Nucleotide-binding]]
[[Category: Nucleotide-binding]]
[[Category: Transmembrane]]
[[Category: Transmembrane]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 07:54:39 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 10:06:37 2008''

Revision as of 07:06, 28 July 2008

Image:2ius.png

Template:STRUCTURE 2ius

E. COLI FTSK MOTOR DOMAIN

Template:ABSTRACT PUBMED 16916635

About this Structure

2IUS is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Double-stranded DNA translocation: structure and mechanism of hexameric FtsK., Massey TH, Mercogliano CP, Yates J, Sherratt DJ, Lowe J, Mol Cell. 2006 Aug;23(4):457-69. PMID:16916635

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