1pah
From Proteopedia
(New page: 200px<br /> <applet load="1pah" size="450" color="white" frame="true" align="right" spinBox="true" caption="1pah, resolution 2.0Å" /> '''HUMAN PHENYLALANINE ...) |
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==About this Structure== | ==About this Structure== | ||
| - | 1PAH is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with FE as [[http://en.wikipedia.org/wiki/ligand ligand]]. The following page contains interesting information on the relation of 1PAH with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb61_1.html Phenylalanine Hydroxylase]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.16.1 1.14.16.1]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1PAH OCA]]. | + | 1PAH is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with FE as [[http://en.wikipedia.org/wiki/ligand ligand]]. The following page contains interesting information on the relation of 1PAH with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb61_1.html Phenylalanine Hydroxylase]]. Active as [[http://en.wikipedia.org/wiki/Phenylalanine_4-monooxygenase Phenylalanine 4-monooxygenase]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.16.1 1.14.16.1]]. Structure known Active Site: NUL. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1PAH OCA]]. |
==Reference== | ==Reference== | ||
Crystal structure of the catalytic domain of human phenylalanine hydroxylase reveals the structural basis for phenylketonuria., Erlandsen H, Fusetti F, Martinez A, Hough E, Flatmark T, Stevens RC, Nat Struct Biol. 1997 Dec;4(12):995-1000. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9406548 9406548] | Crystal structure of the catalytic domain of human phenylalanine hydroxylase reveals the structural basis for phenylketonuria., Erlandsen H, Fusetti F, Martinez A, Hough E, Flatmark T, Stevens RC, Nat Struct Biol. 1997 Dec;4(12):995-1000. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9406548 9406548] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| + | [[Category: Phenylalanine 4-monooxygenase]] | ||
[[Category: Phenylalanine Hydroxylase]] | [[Category: Phenylalanine Hydroxylase]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: pku]] | [[Category: pku]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 12:20:52 2007'' |
Revision as of 10:16, 30 October 2007
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HUMAN PHENYLALANINE HYDROXYLASE DIMER, RESIDUES 117-424
Overview
The 2.0 A crystal structure of the catalytic domain of human phenylalanine, hydroxylase reveals a fold similar to that of tyrosine hydroxylase. It, provides the first structural view of where mutations occur and a, rationale to explain molecular mechanisms of the enzymatic phenotypes in, the autosomal recessive disorder phenylketoneuria.
About this Structure
1PAH is a [Single protein] structure of sequence from [Homo sapiens] with FE as [ligand]. The following page contains interesting information on the relation of 1PAH with [Phenylalanine Hydroxylase]. Active as [Phenylalanine 4-monooxygenase], with EC number [1.14.16.1]. Structure known Active Site: NUL. Full crystallographic information is available from [OCA].
Reference
Crystal structure of the catalytic domain of human phenylalanine hydroxylase reveals the structural basis for phenylketonuria., Erlandsen H, Fusetti F, Martinez A, Hough E, Flatmark T, Stevens RC, Nat Struct Biol. 1997 Dec;4(12):995-1000. PMID:9406548
Page seeded by OCA on Tue Oct 30 12:20:52 2007
