2iy0

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{{STRUCTURE_2iy0| PDB=2iy0 | SCENE= }}
{{STRUCTURE_2iy0| PDB=2iy0 | SCENE= }}
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'''SENP1 (MUTANT) SUMO1 RANGAP'''
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===SENP1 (MUTANT) SUMO1 RANGAP===
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==Overview==
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Small ubiquitin-like modifier (SUMO)-specific protease SENP1 processes SUMO-1, SUMO-2 and SUMO-3 to mature forms and deconjugates them from modified proteins. To establish the proteolytic mechanism, we determined structures of catalytically inactive SENP1 bound to SUMO-1-modified RanGAP1 and to unprocessed SUMO-1. In each case, the scissile peptide bond is kinked at a right angle to the C-terminal tail of SUMO-1 and has the cis configuration of the amide nitrogens. SENP1 preferentially processes SUMO-1 over SUMO-2, but binding thermodynamics of full-length SUMO-1 and SUMO-2 to SENP1 and K(m) values for processing are very similar. However, k(cat) values differ by 50-fold. Thus, discrimination between unprocessed SUMO-1 and SUMO-2 by SENP1 is based on a catalytic step rather than substrate binding and is likely to reflect differences in the ability of SENP1 to correctly orientate the scissile bonds in SUMO-1 and SUMO-2.
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{{ABSTRACT_PUBMED_17099698}}
==About this Structure==
==About this Structure==
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[[Category: Ubiquitin]]
[[Category: Ubiquitin]]
[[Category: Ubl conjugation pathway]]
[[Category: Ubl conjugation pathway]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 08:03:42 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 11:14:38 2008''

Revision as of 08:14, 29 July 2008

Image:2iy0.png

Template:STRUCTURE 2iy0

SENP1 (MUTANT) SUMO1 RANGAP

Template:ABSTRACT PUBMED 17099698

About this Structure

2IY0 is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

SUMO protease SENP1 induces isomerization of the scissile peptide bond., Shen L, Tatham MH, Dong C, Zagorska A, Naismith JH, Hay RT, Nat Struct Mol Biol. 2006 Dec;13(12):1069-77. Epub 2006 Nov 12. PMID:17099698

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