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2iy2

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{{STRUCTURE_2iy2| PDB=2iy2 | SCENE= }}
{{STRUCTURE_2iy2| PDB=2iy2 | SCENE= }}
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'''CRYSTAL STRUCTURE OF THE N-TERMINAL DIMER DOMAIN OF E.COLI DSBG'''
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===CRYSTAL STRUCTURE OF THE N-TERMINAL DIMER DOMAIN OF E.COLI DSBG===
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==Overview==
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DsbC and DsbG are periplasmic disulfide-bond isomerases, enzymes that facilitate the folding of secreted proteins with multiple disulfide bonds by catalyzing disulfide-bond rearrangement. Both enzymes also have in vitro chaperone activity. The crystal structures of these molecules are similar and both are V-shaped homodimeric modular structures. Each dimeric molecule contains two separate C-terminal thioredoxin-fold domains, joined by hinged helical "stalks" to a single N-terminal dimerization domain formed from the N-terminal 67 residues of each monomer. In this work, the crystal structures of the separate DsbC and DsbG dimerization domains have been determined at resolutions of 2.0 and 1.9 A, respectively. The two structures are both similar to the corresponding domains in the full-length molecules, showing that the dimerization domains fold independently of the catalytic portions of the full-length molecules. Localized structural differences between DsbC and DsbG were observed near the dimer interface and may be relevant to the different functions of the two enzymes.
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(as it appears on PubMed at http://www.pubmed.gov), where 17372350 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17372350}}
==About this Structure==
==About this Structure==
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[[Category: Periplasmic]]
[[Category: Periplasmic]]
[[Category: Redox-active center]]
[[Category: Redox-active center]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 08:03:45 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 14:20:03 2008''

Revision as of 11:20, 29 July 2008

Image:2iy2.png

Template:STRUCTURE 2iy2

CRYSTAL STRUCTURE OF THE N-TERMINAL DIMER DOMAIN OF E.COLI DSBG

Template:ABSTRACT PUBMED 17372350

About this Structure

2IY2 is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Structures of the dimerization domains of the Escherichia coli disulfide-bond isomerase enzymes DsbC and DsbG., Yeh SM, Koon N, Squire C, Metcalf P, Acta Crystallogr D Biol Crystallogr. 2007 Apr;63(Pt 4):465-71. Epub 2007, Mar 16. PMID:17372350

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