2iyb

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:2iyb.gif|left|200px]]
+
{{Seed}}
 +
[[Image:2iyb.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_2iyb| PDB=2iyb | SCENE= }}
{{STRUCTURE_2iyb| PDB=2iyb | SCENE= }}
-
'''STRUCTURE OF COMPLEX BETWEEN THE 3RD LIM DOMAIN OF TES AND THE EVH1 DOMAIN OF MENA'''
+
===STRUCTURE OF COMPLEX BETWEEN THE 3RD LIM DOMAIN OF TES AND THE EVH1 DOMAIN OF MENA===
-
==Overview==
+
<!--
-
The intracellular targeting of Ena/VASP family members is achieved via the interaction of their EVH1 domain with FPPPP sequence motifs found in a variety of cytoskeletal proteins, including lamellipodin, vinculin, and zyxin. Here we show that the LIM3 domain of Tes, which lacks the FPPPP motif, binds to the EVH1 domain of Mena, but not to those of VASP or Evl. The structure of the LIM3:EVH1 complex reveals that Tes occludes the FPPPP-binding site and competes with FPPPP-containing proteins for EVH1 binding. Structure-based gain-of-function experiments define the molecular basis for the specificity of the Tes-Mena interaction. Consistent with in vitro observations, the LIM3 domain displaces Mena, but not VASP, from the leading edge and focal adhesions. It also regulates cell migration through a Mena-dependent mechanism. Our observations identify Tes as an atypical EVH1 binding partner and a regulator specific to a single Ena/VASP family member.
+
The line below this paragraph, {{ABSTRACT_PUBMED_18158903}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 18158903 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_18158903}}
==About this Structure==
==About this Structure==
Line 34: Line 38:
[[Category: Tumour supressor lim domain evh1 domain cell motility]]
[[Category: Tumour supressor lim domain evh1 domain cell motility]]
[[Category: Zinc]]
[[Category: Zinc]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 08:04:27 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 19:34:02 2008''

Revision as of 16:34, 28 July 2008

Image:2iyb.png

Template:STRUCTURE 2iyb

STRUCTURE OF COMPLEX BETWEEN THE 3RD LIM DOMAIN OF TES AND THE EVH1 DOMAIN OF MENA

Template:ABSTRACT PUBMED 18158903

About this Structure

2IYB is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Tes, a specific Mena interacting partner, breaks the rules for EVH1 binding., Boeda B, Briggs DC, Higgins T, Garvalov BK, Fadden AJ, McDonald NQ, Way M, Mol Cell. 2007 Dec 28;28(6):1071-82. PMID:18158903

Page seeded by OCA on Mon Jul 28 19:34:02 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2iyb"
Personal tools