2j05

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{{STRUCTURE_2j05| PDB=2j05 | SCENE= }}
{{STRUCTURE_2j05| PDB=2j05 | SCENE= }}
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'''CRYSTAL STRUCTURE OF THE RASGAP SH3 DOMAIN AT 1.5 ANGSTROM RESOLUTION'''
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===CRYSTAL STRUCTURE OF THE RASGAP SH3 DOMAIN AT 1.5 ANGSTROM RESOLUTION===
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==Overview==
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X-ray structures of two crystal forms of the Src homology 3 domain (SH3) of the Ras GTPase activating protein (RasGAP) were determined at 1.5 and 1.8A resolution. The overall structure comprises a single domain with two tightly packed beta-sheets linked by a short helical segment. An important motif for peptide binding in other SH3 domains is not conserved in RasGAP. The RasGAP SH3 domain forms dimers in the crystal structures, which may provide new functional insight. The dimer interface involves residues also present in a peptide previously identified as an apoptotic sensitizer of tumor cells.
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(as it appears on PubMed at http://www.pubmed.gov), where 17188236 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17188236}}
==About this Structure==
==About this Structure==
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[[Category: Signal transduction]]
[[Category: Signal transduction]]
[[Category: Src homology 3]]
[[Category: Src homology 3]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 08:09:06 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 13:47:53 2008''

Revision as of 10:47, 29 July 2008

Image:2j05.png

Template:STRUCTURE 2j05

CRYSTAL STRUCTURE OF THE RASGAP SH3 DOMAIN AT 1.5 ANGSTROM RESOLUTION

Template:ABSTRACT PUBMED 17188236

About this Structure

2J05 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

High resolution crystal structures of the p120 RasGAP SH3 domain., Ross B, Kristensen O, Favre D, Walicki J, Kastrup JS, Widmann C, Gajhede M, Biochem Biophys Res Commun. 2007 Feb 9;353(2):463-8. Epub 2006 Dec 18. PMID:17188236

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