2j2z

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{{Seed}}
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[[Image:2j2z.png|left|200px]]
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{{STRUCTURE_2j2z| PDB=2j2z | SCENE= }}
{{STRUCTURE_2j2z| PDB=2j2z | SCENE= }}
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'''X-RAY STRUCTURE OF THE CHAPERONE PAPD IN COMPLEX WITH THE PILUS TERMINATOR SUBUNIT PAPH AT 2.3 ANGSTROM RESOLUTION'''
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===X-RAY STRUCTURE OF THE CHAPERONE PAPD IN COMPLEX WITH THE PILUS TERMINATOR SUBUNIT PAPH AT 2.3 ANGSTROM RESOLUTION===
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==Overview==
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P pili are important adhesive fibres that are assembled by the conserved chaperone-usher pathway. During pilus assembly, the subunits are incorporated into the growing fibre by the donor-strand exchange mechanism, whereby the beta-strand of the chaperone, which complements the incomplete immunoglobulin fold of each subunit, is displaced by the amino-terminal extension of an incoming subunit in a zip-in-zip-out exchange process that is initiated at the P5 pocket, an exposed hydrophobic pocket in the groove of the subunit. In vivo, termination of P pilus growth requires a specialized subunit, PapH. Here, we show that PapH is incorporated at the base of the growing pilus, where it is unable to undergo donor-strand exchange. This inability is not due to a stronger PapD-PapH interaction, but to a lack of a P5 initiator pocket in the PapH structure, suggesting that PapH terminates pilus growth because it is lacking the initiation point by which donor-strand exchange proceeds.
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(as it appears on PubMed at http://www.pubmed.gov), where 17082819 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17082819}}
==About this Structure==
==About this Structure==
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[[Category: Periplasmic]]
[[Category: Periplasmic]]
[[Category: Pilus termination]]
[[Category: Pilus termination]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 08:15:43 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 05:13:34 2008''

Revision as of 02:13, 28 July 2008

Image:2j2z.png

Template:STRUCTURE 2j2z

X-RAY STRUCTURE OF THE CHAPERONE PAPD IN COMPLEX WITH THE PILUS TERMINATOR SUBUNIT PAPH AT 2.3 ANGSTROM RESOLUTION

Template:ABSTRACT PUBMED 17082819

About this Structure

2J2Z is a Protein complex structure of sequences from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Molecular mechanism of P pilus termination in uropathogenic Escherichia coli., Verger D, Miller E, Remaut H, Waksman G, Hultgren S, EMBO Rep. 2006 Dec;7(12):1228-32. Epub 2006 Nov 3. PMID:17082819

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