2j48

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{{STRUCTURE_2j48| PDB=2j48 | SCENE= }}
{{STRUCTURE_2j48| PDB=2j48 | SCENE= }}
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'''NMR STRUCTURE OF THE PSEUDO-RECEIVER DOMAIN OF THE CIKA PROTEIN.'''
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===NMR STRUCTURE OF THE PSEUDO-RECEIVER DOMAIN OF THE CIKA PROTEIN.===
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==Overview==
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The circadian input kinase (CikA) is a major element of the pathway that provides environmental information to the circadian clock of the cyanobacterium Synechococcus elongatus. CikA is a polypeptide of 754 residues and has three recognizable domains: GAF, histidine protein kinase, and receiver-like. This latter domain of CikA lacks the conserved phospho-accepting aspartyl residue of bona fide receiver domains and is thus a pseudo-receiver (PsR). Recently, it was shown that the PsR domain (1) attenuates the autokinase activity of CikA, (2) is necessary to localize CikA to the cell pole, and (3) is necessary for the destabilization of CikA in the presence of the quinone analog 2,5-dibromo-3-methyl-6-isopropyl-p-benzoquinone (DBMIB). The solution structure of the PsR domain of CikA, CikAPsR, is presented here. A model of the interaction between the PsR domain and HPK portion of CikA provides a potential explanation for how the PsR domain attenuates the autokinase activity of CikA. Finally, a likely quinone-binding surface on CikAPsR is shown here.
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(as it appears on PubMed at http://www.pubmed.gov), where 17322531 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17322531}}
==About this Structure==
==About this Structure==
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2J48 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Synechococcus_elongatus Synechococcus elongatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J48 OCA].
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2J48 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Synechococcus_elongatus Synechococcus elongatus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J48 OCA].
==Reference==
==Reference==
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[[Category: Response regulator]]
[[Category: Response regulator]]
[[Category: Transferase]]
[[Category: Transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 08:18:25 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 22:24:31 2008''

Revision as of 19:24, 28 July 2008

Image:2j48.png

Template:STRUCTURE 2j48

NMR STRUCTURE OF THE PSEUDO-RECEIVER DOMAIN OF THE CIKA PROTEIN.

Template:ABSTRACT PUBMED 17322531

About this Structure

2J48 is a Single protein structure of sequence from Synechococcus elongatus. Full experimental information is available from OCA.

Reference

NMR structure of the pseudo-receiver domain of CikA., Gao T, Zhang X, Ivleva NB, Golden SS, LiWang A, Protein Sci. 2007 Mar;16(3):465-75. PMID:17322531

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