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2j4d

From Proteopedia

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[[Image:2j4d.jpg|left|200px]]
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{{Seed}}
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{{STRUCTURE_2j4d| PDB=2j4d | SCENE= }}
{{STRUCTURE_2j4d| PDB=2j4d | SCENE= }}
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'''CRYPTOCHROME 3 FROM ARABIDOPSIS THALIANA'''
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===CRYPTOCHROME 3 FROM ARABIDOPSIS THALIANA===
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==Overview==
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Cryptochromes are almost ubiquitous blue-light receptors and act in several species as central components of the circadian clock. Despite being evolutionary and structurally related with DNA photolyases, a class of light-driven DNA-repair enzymes, and having similar cofactor compositions, cryptochromes lack DNA-repair activity. Cryptochrome 3 from the plant Arabidopsis thaliana belongs to the DASH-type subfamily. Its crystal structure determined at 1.9 Angstroms resolution shows cryptochrome 3 in a dimeric state with the antenna cofactor 5,10-methenyltetrahydrofolate (MTHF) bound in a distance of 15.2 Angstroms to the U-shaped FAD chromophore. Spectroscopic studies on a mutant where a residue crucial for MTHF-binding, E149, was replaced by site-directed mutagenesis demonstrate that MTHF acts in cryptochrome 3 as a functional antenna for the photoreduction of FAD.
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(as it appears on PubMed at http://www.pubmed.gov), where 17188299 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17188299}}
==About this Structure==
==About this Structure==
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==Reference==
==Reference==
Cryptochrome 3 from Arabidopsis thaliana: structural and functional analysis of its complex with a folate light antenna., Klar T, Pokorny R, Moldt J, Batschauer A, Essen LO, J Mol Biol. 2007 Feb 23;366(3):954-64. Epub 2006 Dec 2. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17188299 17188299]
Cryptochrome 3 from Arabidopsis thaliana: structural and functional analysis of its complex with a folate light antenna., Klar T, Pokorny R, Moldt J, Batschauer A, Essen LO, J Mol Biol. 2007 Feb 23;366(3):954-64. Epub 2006 Dec 2. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17188299 17188299]
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Crystallization and preliminary X-ray analysis of cryptochrome 3 from Arabidopsis thaliana., Pokorny R, Klar T, Essen LO, Batschauer A, Acta Crystallogr Sect F Struct Biol Cryst Commun. 2005 Oct 1;61(Pt, 10):935-8. Epub 2005 Sep 30. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16511200 16511200]
[[Category: Arabidopsis thaliana]]
[[Category: Arabidopsis thaliana]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: Plastid]]
[[Category: Plastid]]
[[Category: Transit peptide]]
[[Category: Transit peptide]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 08:18:51 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 08:17:36 2008''

Revision as of 05:17, 29 July 2008

Image:2j4d.png

Template:STRUCTURE 2j4d

CRYPTOCHROME 3 FROM ARABIDOPSIS THALIANA

Template:ABSTRACT PUBMED 17188299

About this Structure

2J4D is a Single protein structure of sequence from Arabidopsis thaliana. Full crystallographic information is available from OCA.

Reference

Cryptochrome 3 from Arabidopsis thaliana: structural and functional analysis of its complex with a folate light antenna., Klar T, Pokorny R, Moldt J, Batschauer A, Essen LO, J Mol Biol. 2007 Feb 23;366(3):954-64. Epub 2006 Dec 2. PMID:17188299

Crystallization and preliminary X-ray analysis of cryptochrome 3 from Arabidopsis thaliana., Pokorny R, Klar T, Essen LO, Batschauer A, Acta Crystallogr Sect F Struct Biol Cryst Commun. 2005 Oct 1;61(Pt, 10):935-8. Epub 2005 Sep 30. PMID:16511200

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