2j4r

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{{STRUCTURE_2j4r| PDB=2j4r | SCENE= }}
{{STRUCTURE_2j4r| PDB=2j4r | SCENE= }}
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'''STRUCTURAL STUDY OF THE AQUIFEX AEOLICUS PPX-GPPA ENZYME'''
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===STRUCTURAL STUDY OF THE AQUIFEX AEOLICUS PPX-GPPA ENZYME===
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==Overview==
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The crystal structure of the prototype exopolyphosphatase/guanosine pentaphosphate phosphohydrolase protein family member from Aquifex aeolicus in complex with the intracellular second messenger guanosine tetraphosphate was determined at 2.7-A resolution. The hydrolytic base is identified as E119. The dual specificity established for the Escherichia coli homolog is shown to be compatible with a common active site for guanosine pentaphosphate and polyphosphate hydrolysis. Distinct and different degrees of closure between the two domains of the enzyme are associated with substrate binding. The arginines R22 and R267, residing in different domains, are crucial for guanosine pentaphosphate specificity as they interact with the unique 3'-ribose phosphorylation.
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(as it appears on PubMed at http://www.pubmed.gov), where 18155044 is the PubMed ID number.
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{{ABSTRACT_PUBMED_18155044}}
==About this Structure==
==About this Structure==
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==Reference==
==Reference==
Structure of the PPX/GPPA phosphatase from Aquifex aeolicus in complex with the alarmone ppGpp., Kristensen O, Ross B, Gajhede M, J Mol Biol. 2008 Feb 1;375(5):1469-76. Epub 2007 Dec 4. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18155044 18155044]
Structure of the PPX/GPPA phosphatase from Aquifex aeolicus in complex with the alarmone ppGpp., Kristensen O, Ross B, Gajhede M, J Mol Biol. 2008 Feb 1;375(5):1469-76. Epub 2007 Dec 4. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18155044 18155044]
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Structural characterization of the stringent response related exopolyphosphatase/guanosine pentaphosphate phosphohydrolase protein family., Kristensen O, Laurberg M, Liljas A, Kastrup JS, Gajhede M, Biochemistry. 2004 Jul 20;43(28):8894-900. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15248747 15248747]
[[Category: Aquifex aeolicus]]
[[Category: Aquifex aeolicus]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: Ppgpp]]
[[Category: Ppgpp]]
[[Category: Stringent response]]
[[Category: Stringent response]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 08:19:58 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 11:13:49 2008''

Revision as of 08:13, 28 July 2008

Image:2j4r.png

Template:STRUCTURE 2j4r

STRUCTURAL STUDY OF THE AQUIFEX AEOLICUS PPX-GPPA ENZYME

Template:ABSTRACT PUBMED 18155044

About this Structure

2J4R is a Single protein structure of sequence from Aquifex aeolicus. Full crystallographic information is available from OCA.

Reference

Structure of the PPX/GPPA phosphatase from Aquifex aeolicus in complex with the alarmone ppGpp., Kristensen O, Ross B, Gajhede M, J Mol Biol. 2008 Feb 1;375(5):1469-76. Epub 2007 Dec 4. PMID:18155044

Structural characterization of the stringent response related exopolyphosphatase/guanosine pentaphosphate phosphohydrolase protein family., Kristensen O, Laurberg M, Liljas A, Kastrup JS, Gajhede M, Biochemistry. 2004 Jul 20;43(28):8894-900. PMID:15248747

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