2j4x

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{{STRUCTURE_2j4x| PDB=2j4x | SCENE= }}
{{STRUCTURE_2j4x| PDB=2j4x | SCENE= }}
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'''STREPTOCOCCUS DYSGALACTIAE-DERIVED MITOGEN (SDM)'''
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===STREPTOCOCCUS DYSGALACTIAE-DERIVED MITOGEN (SDM)===
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==Overview==
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Bacterial superantigens are protein toxins with an ability to cause serious diseases in humans by activating a large number of T cells. Streptococcus dysgalactiae-derived mitogen (SDM) is a novel superantigen that is distinct from other known superantigens based on phylogenetic analysis. The X-ray structure of SDM has been determined at 1.95 A resolution. SDM shares the same characteristic fold with other superantigens, but it shows a major structural difference due to the lack of the alpha5 helix between the beta10 and beta11 strands. A bound zinc ion was identified in the structure at the C-terminal domain of the molecule. SDM appears to bind to the major histocompatibility complex class II beta-chain through the zinc-binding site, as described by mutagenesis data and structural comparisons. T-cell binding instead shows a significant difference compared to other superantigens. The mutation of Asn11 (a conserved residue that is known to be significant for T-cell-receptor binding in other superantigens) and Lys15 to Ala did not cause any decrease in the mitogenic activity of SDM. This observation and the lack of the alpha5 helix suggest alterations in T-cell-receptor binding.
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{{ABSTRACT_PUBMED_17900619}}
==About this Structure==
==About this Structure==
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[[Category: Bacterial superantigen]]
[[Category: Bacterial superantigen]]
[[Category: Signaling protein]]
[[Category: Signaling protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 08:20:17 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 00:08:13 2008''

Revision as of 21:08, 28 July 2008

Image:2j4x.png

Template:STRUCTURE 2j4x

STREPTOCOCCUS DYSGALACTIAE-DERIVED MITOGEN (SDM)

Template:ABSTRACT PUBMED 17900619

About this Structure

2J4X is a Single protein structure of sequence from Streptococcus dysgalactiae. Full crystallographic information is available from OCA.

Reference

Crystal structure of Streptococcus dysgalactiae-derived mitogen reveals a zinc-binding site and alterations in TcR binding., Saarinen S, Kato H, Uchiyama T, Miyoshi-Akiyama T, Papageorgiou AC, J Mol Biol. 2007 Nov 9;373(5):1089-97. Epub 2007 Aug 21. PMID:17900619

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