2j53

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:2j53.jpg|left|200px]]
+
{{Seed}}
 +
[[Image:2j53.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_2j53| PDB=2j53 | SCENE= }}
{{STRUCTURE_2j53| PDB=2j53 | SCENE= }}
-
'''SOLUTION STRUCTURE OF GB1 DOMAIN PROTEIN G AND LOW AND HIGH PRESSURE.'''
+
===SOLUTION STRUCTURE OF GB1 DOMAIN PROTEIN G AND LOW AND HIGH PRESSURE.===
-
==Overview==
+
<!--
-
The solution structure of the GB1 domain of protein G at a pressure of 2 kbar is presented. The structure was calculated as a change from an energy-minimised low-pressure structure using (1)H chemical shifts. Two separate changes can be characterised: a compression/distortion, which is linear with pressure; and a stabilisation of an alternative folded state. On application of pressure, linear chemical shift changes reveal that the backbone structure changes by about 0.2 A root mean square, and is compressed by about 1% overall. The alpha-helix compresses, particularly at the C-terminal end, and moves toward the beta-sheet, while the beta-sheet is twisted, with the corners closest to the alpha-helix curling up towards it. The largest changes in structure are along the second beta-strand, which becomes more twisted. This strand is where the protein binds to IgG. Curved chemical shift changes with pressure indicate that high pressure also populates an alternative structure with a distortion towards the C-terminal end of the helix, which is likely to be caused by insertion of a water molecule. Proteins 2007. (c) 2007 Wiley-Liss, Inc.
+
The line below this paragraph, {{ABSTRACT_PUBMED_18076052}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 18076052 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_18076052}}
==About this Structure==
==About this Structure==
-
2J53 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Streptococcus_sp. Streptococcus sp.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J53 OCA].
+
2J53 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Streptococcus_sp. Streptococcus sp.]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J53 OCA].
==Reference==
==Reference==
Line 33: Line 37:
[[Category: Pressure]]
[[Category: Pressure]]
[[Category: Protein g]]
[[Category: Protein g]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 08:20:53 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 15:51:39 2008''

Revision as of 12:51, 29 July 2008

Image:2j53.png

Template:STRUCTURE 2j53

SOLUTION STRUCTURE OF GB1 DOMAIN PROTEIN G AND LOW AND HIGH PRESSURE.

Template:ABSTRACT PUBMED 18076052

About this Structure

2J53 is a Single protein structure of sequence from Streptococcus sp.. Full experimental information is available from OCA.

Reference

Pressure-induced changes in the solution structure of the GB1 domain of protein G., Wilton DJ, Tunnicliffe RB, Kamatari YO, Akasaka K, Williamson MP, Proteins. 2007 Dec 12;. PMID:18076052

Page seeded by OCA on Tue Jul 29 15:51:39 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2j53"
Personal tools