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2j52

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[[Image:2j52.jpg|left|200px]]
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[[Image:2j52.png|left|200px]]
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{{STRUCTURE_2j52| PDB=2j52 | SCENE= }}
{{STRUCTURE_2j52| PDB=2j52 | SCENE= }}
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'''SOLUTION STRUCTURE OF GB1 DOMAIN PROTEIN G AND LOW AND HIGH PRESSURE.'''
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===SOLUTION STRUCTURE OF GB1 DOMAIN PROTEIN G AND LOW AND HIGH PRESSURE.===
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==Overview==
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The solution structure of the GB1 domain of protein G at a pressure of 2 kbar is presented. The structure was calculated as a change from an energy-minimised low-pressure structure using (1)H chemical shifts. Two separate changes can be characterised: a compression/distortion, which is linear with pressure; and a stabilisation of an alternative folded state. On application of pressure, linear chemical shift changes reveal that the backbone structure changes by about 0.2 A root mean square, and is compressed by about 1% overall. The alpha-helix compresses, particularly at the C-terminal end, and moves toward the beta-sheet, while the beta-sheet is twisted, with the corners closest to the alpha-helix curling up towards it. The largest changes in structure are along the second beta-strand, which becomes more twisted. This strand is where the protein binds to IgG. Curved chemical shift changes with pressure indicate that high pressure also populates an alternative structure with a distortion towards the C-terminal end of the helix, which is likely to be caused by insertion of a water molecule. Proteins 2007. (c) 2007 Wiley-Liss, Inc.
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The line below this paragraph, {{ABSTRACT_PUBMED_18076052}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 18076052 is the PubMed ID number.
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{{ABSTRACT_PUBMED_18076052}}
==About this Structure==
==About this Structure==
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2J52 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Streptococcus_sp. Streptococcus sp.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J52 OCA].
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2J52 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Streptococcus_sp. Streptococcus sp.]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J52 OCA].
==Reference==
==Reference==
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[[Category: Pressure]]
[[Category: Pressure]]
[[Category: Protein g]]
[[Category: Protein g]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 08:20:51 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 07:19:52 2008''

Revision as of 04:19, 28 July 2008

Image:2j52.png

Template:STRUCTURE 2j52

SOLUTION STRUCTURE OF GB1 DOMAIN PROTEIN G AND LOW AND HIGH PRESSURE.

Template:ABSTRACT PUBMED 18076052

About this Structure

2J52 is a Single protein structure of sequence from Streptococcus sp.. Full experimental information is available from OCA.

Reference

Pressure-induced changes in the solution structure of the GB1 domain of protein G., Wilton DJ, Tunnicliffe RB, Kamatari YO, Akasaka K, Williamson MP, Proteins. 2007 Dec 12;. PMID:18076052

Page seeded by OCA on Mon Jul 28 07:19:52 2008

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