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2j58

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[[Image:2j58.jpg|left|200px]]
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{{STRUCTURE_2j58| PDB=2j58 | SCENE= }}
{{STRUCTURE_2j58| PDB=2j58 | SCENE= }}
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'''THE STRUCTURE OF WZA'''
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===THE STRUCTURE OF WZA===
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==Overview==
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Many types of bacteria produce extracellular polysaccharides (EPSs). Some are secreted polymers and show only limited association with the cell surface, whereas others are firmly attached to the cell surface and form a discrete structural layer, the capsule, which envelopes the cell and allows the bacteria to evade or counteract the host immune system. EPSs have critical roles in bacterial colonization of surfaces, such as epithelia and medical implants; in addition some EPSs have important industrial and biomedical applications in their own right. Here we describe the 2.26 A resolution structure of the 340 kDa octamer of Wza, an integral outer membrane lipoprotein, which is essential for group 1 capsule export in Escherichia coli. The transmembrane region is a novel alpha-helical barrel. The bulk of the Wza structure is located in the periplasm and comprises three novel domains forming a large central cavity. Wza is open to the extracellular environment but closed to the periplasm. We propose a route and mechanism for translocation of the capsular polysaccharide. This work may provide insight into the export of other large polar molecules such as DNA and proteins.
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The line below this paragraph, {{ABSTRACT_PUBMED_17086202}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 17086202 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17086202}}
==About this Structure==
==About this Structure==
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[[Category: Lipoprotein]]
[[Category: Lipoprotein]]
[[Category: Membrane protein]]
[[Category: Membrane protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 08:21:17 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 00:37:14 2008''

Revision as of 21:37, 28 July 2008

Image:2j58.png

Template:STRUCTURE 2j58

THE STRUCTURE OF WZA

Template:ABSTRACT PUBMED 17086202

About this Structure

2J58 is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Wza the translocon for E. coli capsular polysaccharides defines a new class of membrane protein., Dong C, Beis K, Nesper J, Brunkan-Lamontagne AL, Clarke BR, Whitfield C, Naismith JH, Nature. 2006 Nov 9;444(7116):226-9. Epub 2006 Nov 1. PMID:17086202

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