2j5y

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{{STRUCTURE_2j5y| PDB=2j5y | SCENE= }}
{{STRUCTURE_2j5y| PDB=2j5y | SCENE= }}
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'''CRYSTAL STRUCTURE OF THE GA MODULE FROM F.MAGNA'''
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===CRYSTAL STRUCTURE OF THE GA MODULE FROM F.MAGNA===
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==Overview==
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The albumin-binding domain, or GA module, of the peptostreptococcal albumin-binding protein expressed in pathogenic strains of Finegoldia magna is believed to be responsible for the virulence and increased growth rate of these strains. Here we present the 1.4A crystal structure of this domain, and compare it with the crystal structure of the GA-albumin complex. An analysis of protein-protein interactions in the two crystals, and the presence of multimeric GA species in solution, indicate the GA module is "sticky", and is capable of forming contacts with a range of protein surfaces. This might lead to interactions with different host proteins.
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(as it appears on PubMed at http://www.pubmed.gov), where 17575979 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17575979}}
==About this Structure==
==About this Structure==
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==Reference==
==Reference==
Crystal structure of a bacterial albumin-binding domain at 1.4 A resolution., Cramer JF, Nordberg PA, Hajdu J, Lejon S, FEBS Lett. 2007 Jul 10;581(17):3178-82. Epub 2007 Jun 12. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17575979 17575979]
Crystal structure of a bacterial albumin-binding domain at 1.4 A resolution., Cramer JF, Nordberg PA, Hajdu J, Lejon S, FEBS Lett. 2007 Jul 10;581(17):3178-82. Epub 2007 Jun 12. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17575979 17575979]
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Crystal structure and biological implications of a bacterial albumin binding module in complex with human serum albumin., Lejon S, Frick IM, Bjorck L, Wikstrom M, Svensson S, J Biol Chem. 2004 Oct 8;279(41):42924-8. Epub 2004 Jul 21. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15269208 15269208]
[[Category: Finegoldia magna]]
[[Category: Finegoldia magna]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: Peptidoglycan-anchor]]
[[Category: Peptidoglycan-anchor]]
[[Category: Protein binding bacterial albumin-binding three-helix bundle]]
[[Category: Protein binding bacterial albumin-binding three-helix bundle]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 08:23:28 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 10:05:26 2008''

Revision as of 07:05, 29 July 2008

Image:2j5y.png

Template:STRUCTURE 2j5y

CRYSTAL STRUCTURE OF THE GA MODULE FROM F.MAGNA

Template:ABSTRACT PUBMED 17575979

About this Structure

2J5Y is a Single protein structure of sequence from Finegoldia magna. Full crystallographic information is available from OCA.

Reference

Crystal structure of a bacterial albumin-binding domain at 1.4 A resolution., Cramer JF, Nordberg PA, Hajdu J, Lejon S, FEBS Lett. 2007 Jul 10;581(17):3178-82. Epub 2007 Jun 12. PMID:17575979

Crystal structure and biological implications of a bacterial albumin binding module in complex with human serum albumin., Lejon S, Frick IM, Bjorck L, Wikstrom M, Svensson S, J Biol Chem. 2004 Oct 8;279(41):42924-8. Epub 2004 Jul 21. PMID:15269208

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