2j6v

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[[Image:2j6v.gif|left|200px]]
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{{Seed}}
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[[Image:2j6v.png|left|200px]]
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{{STRUCTURE_2j6v| PDB=2j6v | SCENE= }}
{{STRUCTURE_2j6v| PDB=2j6v | SCENE= }}
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'''CRYSTAL STRUCTURE OF THE DNA REPAIR ENZYME UV DAMAGE ENDONUC'''
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===CRYSTAL STRUCTURE OF THE DNA REPAIR ENZYME UV DAMAGE ENDONUC===
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==Overview==
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The ultraviolet damage endonuclease (UVDE) performs the initial step in an alternative excision repair pathway of UV-induced DNA damage, nicking immediately adjacent to the 5' phosphate of the damaged nucleotides. Unique for a single-protein DNA repair endonuclease, it can detect different types of damage. Here we show that Thermus thermophilus UVDE shares some essential structural features with Endo IV, an enzyme from the base excision repair pathway that exclusively nicks at abasic sites. A comparison between the structures indicates how DNA is bound by UVDE, how UVDE may recognize damage, and which of its residues are involved in catalysis. Furthermore, the comparison suggests an elegant explanation of UVDE's potential to recognize different types of damage. Incision assays including point mutants of UVDE confirmed the relevance of these conclusions.
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(as it appears on PubMed at http://www.pubmed.gov), where 17937920 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17937920}}
==About this Structure==
==About this Structure==
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[[Category: Tim barrel]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 08:26:02 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 12:54:04 2008''

Revision as of 09:54, 27 July 2008

Image:2j6v.png

Template:STRUCTURE 2j6v

CRYSTAL STRUCTURE OF THE DNA REPAIR ENZYME UV DAMAGE ENDONUC

Template:ABSTRACT PUBMED 17937920

About this Structure

2J6V is a Single protein structure of sequence from Thermus thermophilus. Full crystallographic information is available from OCA.

Reference

Crystal structure of the DNA repair enzyme ultraviolet damage endonuclease., Paspaleva K, Thomassen E, Pannu NS, Iwai S, Moolenaar GF, Goosen N, Abrahams JP, Structure. 2007 Oct;15(10):1316-24. PMID:17937920

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