2j6x

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{{STRUCTURE_2j6x| PDB=2j6x | SCENE= }}
{{STRUCTURE_2j6x| PDB=2j6x | SCENE= }}
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'''THE CRYSTAL STRUCTURE OF LACTATE OXIDASE'''
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===THE CRYSTAL STRUCTURE OF LACTATE OXIDASE===
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==Overview==
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The crystal structure of L-lactate oxidase (LOX) from Aerococcus viridans has been determined at 2.1 A resolution. LOX catalyzes the flavin mononucleotide (FMN) dependent oxidation of lactate to pyruvate and hydrogen peroxide. LOX belongs to the alpha-hydroxy-acid oxidase flavoenzyme family; members of which bind similar substrates and to some extent have conserved catalytic properties and structural motifs. LOX crystallized as two tightly packed tetramers in the asymmetric unit, each having fourfold symmetry. The present structure shows a conserved FMN coordination, but also reveals novel residues involved in substrate binding compared with other family members.
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{{ABSTRACT_PUBMED_17142893}}
==About this Structure==
==About this Structure==
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[[Category: Fmn-dependent]]
[[Category: Fmn-dependent]]
[[Category: Oxidoreductase]]
[[Category: Oxidoreductase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 08:26:10 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 23:40:12 2008''

Revision as of 20:40, 27 July 2008

Image:2j6x.png

Template:STRUCTURE 2j6x

THE CRYSTAL STRUCTURE OF LACTATE OXIDASE

Template:ABSTRACT PUBMED 17142893

About this Structure

2J6X is a Single protein structure of sequence from Aerococcus viridans. Full crystallographic information is available from OCA.

Reference

The 2.1 A structure of Aerococcus viridans L-lactate oxidase (LOX)., Leiros I, Wang E, Rasmussen T, Oksanen E, Repo H, Petersen SB, Heikinheimo P, Hough E, Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006 Dec 1;62(Pt, 12):1185-90. Epub 2006 Nov 4. PMID:17142893

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