2j7m

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{{Seed}}
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{{STRUCTURE_2j7m| PDB=2j7m | SCENE= }}
{{STRUCTURE_2j7m| PDB=2j7m | SCENE= }}
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'''CHARACTERIZATION OF A FAMILY 32 CBM'''
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===CHARACTERIZATION OF A FAMILY 32 CBM===
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==Overview==
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Clostridium perfringens is a notable colonizer of the human gastrointestinal tract. This bacterium is quite remarkable for a human pathogen by the number of glycoside hydrolases found in its genome. The modularity of these enzymes is striking as is the frequent occurrence of modules having amino acid sequence identity with family 32 carbohydrate-binding modules (CBMs), often referred to as F5/8 domains. Here we report the properties of family 32 CBMs from a C. perfringens N-acetyl-beta-hexosaminidase. Macroarray, UV difference, and isothermal titration calorimetry binding studies indicate a preference for the disaccharide LacNAc (beta-d-galactosyl-1,4-beta-d-N-acetylglucosamine). The molecular details of the interaction of this CBM with galactose, LacNAc, and the type II blood group H-trisaccharide are revealed by x-ray crystallographic studies at resolutions of 1.49, 2.4, and 2.3 A, respectively.
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The line below this paragraph, {{ABSTRACT_PUBMED_16990278}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 16990278 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16990278}}
==About this Structure==
==About this Structure==
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[[Category: H-trisaccharide]]
[[Category: H-trisaccharide]]
[[Category: Hydrolase]]
[[Category: Hydrolase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 08:27:54 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 20:40:41 2008''

Revision as of 17:40, 27 July 2008

Image:2j7m.png

Template:STRUCTURE 2j7m

CHARACTERIZATION OF A FAMILY 32 CBM

Template:ABSTRACT PUBMED 16990278

About this Structure

2J7M is a Single protein structure of sequence from Clostridium perfringens. This structure supersedes the now removed PDB entry 2j1f. Full crystallographic information is available from OCA.

Reference

The interaction of a carbohydrate-binding module from a Clostridium perfringens N-acetyl-beta-hexosaminidase with its carbohydrate receptor., Ficko-Blean E, Boraston AB, J Biol Chem. 2006 Dec 8;281(49):37748-57. Epub 2006 Sep 21. PMID:16990278

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