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2j7o

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{{STRUCTURE_2j7o| PDB=2j7o | SCENE= }}
{{STRUCTURE_2j7o| PDB=2j7o | SCENE= }}
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'''STRUCTURE OF THE RNAI POLYMERASE FROM NEUROSPORA CRASSA'''
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===STRUCTURE OF THE RNAI POLYMERASE FROM NEUROSPORA CRASSA===
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==Overview==
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RNA silencing refers to a group of RNA-induced gene-silencing mechanisms that developed early in the eukaryotic lineage, probably for defence against pathogens and regulation of gene expression. In plants, protozoa, fungi, and nematodes, but apparently not insects and vertebrates, it involves a cell-encoded RNA-dependent RNA polymerase (cRdRP) that produces double-stranded RNA triggers from aberrant single-stranded RNA. We report the 2.3-A resolution crystal structure of QDE-1, a cRdRP from Neurospora crassa, and find that it forms a relatively compact dimeric molecule, each subunit of which comprises several domains with, at its core, a catalytic apparatus and protein fold strikingly similar to the catalytic core of the DNA-dependent RNA polymerases responsible for transcription. This evolutionary link between the two enzyme types suggests that aspects of RNA silencing in some organisms may recapitulate transcription/replication pathways functioning in the ancient RNA-based world.
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{{ABSTRACT_PUBMED_17147473}}
==About this Structure==
==About this Structure==
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[[Category: Rna-directed rna polymerase]]
[[Category: Rna-directed rna polymerase]]
[[Category: Rnai response]]
[[Category: Rnai response]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 08:28:09 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 10:52:24 2008''

Revision as of 07:52, 29 July 2008

Image:2j7o.png

Template:STRUCTURE 2j7o

STRUCTURE OF THE RNAI POLYMERASE FROM NEUROSPORA CRASSA

Template:ABSTRACT PUBMED 17147473

About this Structure

2J7O is a Single protein structure of sequence from Neurospora crassa. Full crystallographic information is available from OCA.

Reference

The structure of an RNAi polymerase links RNA silencing and transcription., Salgado PS, Koivunen MR, Makeyev EV, Bamford DH, Stuart DI, Grimes JM, PLoS Biol. 2006 Dec;4(12):e434. PMID:17147473

Page seeded by OCA on Tue Jul 29 10:52:24 2008

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