2z6o
From Proteopedia
(New page: 200px<br /> <applet load="2z6o" size="450" color="white" frame="true" align="right" spinBox="true" caption="2z6o, resolution 1.60Å" /> '''Crystal Structure o...) |
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| - | [[Image:2z6o.gif|left|200px]]<br /> | + | [[Image:2z6o.gif|left|200px]]<br /><applet load="2z6o" size="350" color="white" frame="true" align="right" spinBox="true" |
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caption="2z6o, resolution 1.60Å" /> | caption="2z6o, resolution 1.60Å" /> | ||
'''Crystal Structure of the Ufc1, Ufm1 conjugating enzyme 1'''<br /> | '''Crystal Structure of the Ufc1, Ufm1 conjugating enzyme 1'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 2Z6O is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with MG as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Ubiquitin--protein_ligase Ubiquitin--protein ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.2.19 6.3.2.19] Full crystallographic information is available from [http:// | + | 2Z6O is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=MG:'>MG</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Ubiquitin--protein_ligase Ubiquitin--protein ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.2.19 6.3.2.19] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z6O OCA]. |
==Reference== | ==Reference== | ||
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[[Category: ufm1]] | [[Category: ufm1]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 23 13:31:24 2008'' |
Revision as of 11:31, 23 January 2008
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Crystal Structure of the Ufc1, Ufm1 conjugating enzyme 1
Overview
Ubiquitin and ubiquitin-like protein-conjugating enzymes play central, roles in posttranslational modification processes. The ubiquitin-fold, modifier 1 (Ufm1), one of a variety of ubiquitin-like modifiers, is, covalently attached to target proteins via Uba5 and Ufm1-conjugating, enzyme 1 (Ufc1), which are analogous to the E1 and E2 ubiquitylation, enzymes. As Ufm1-related proteins are conserved in metazoa and plants, the, Ufm1 system likely plays important roles in various multicellular, organisms. Herein, we report the X-ray structure of human Ufc1 determined, at 1.6A resolution. The Ufc1 structure comprises a canonical E2 domain and, an additional N-terminal domain. The Uba5 binding site on Ufc1 was, assigned by structural comparison of Ufc1 and Ubc12 and related mutational, analyses. In addition, we show that the N-terminal unique domain of Ufc1, contributes to thermal stability.
About this Structure
2Z6O is a Single protein structure of sequence from Homo sapiens with as ligand. Active as Ubiquitin--protein ligase, with EC number 6.3.2.19 Full crystallographic information is available from OCA.
Reference
Crystal structure of Ufc1, the Ufm1-conjugating enzyme., Mizushima T, Tatsumi K, Ozaki Y, Kawakami T, Suzuki A, Ogasahara K, Komatsu M, Kominami E, Tanaka K, Yamane T, Biochem Biophys Res Commun. 2007 Nov 3;362(4):1079-84. Epub 2007 Aug 30. PMID:17825256
Page seeded by OCA on Wed Jan 23 13:31:24 2008
Categories: Homo sapiens | Single protein | Ubiquitin--protein ligase | Kawakami, T. | Komatsu, M. | Kominami, E. | Mizushima ,T. | Ogasahara, K. | Ozaki, Y. | Suzuki, A. | Tanaka, K. | Tatsumi, K. | Yamane, T. | MG | Ligase | Polymorphism | Ubiquitin | Ubl | Ubl conjugation pathway | Ufc1 | Ufm1
