2j8h

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{{STRUCTURE_2j8h| PDB=2j8h | SCENE= }}
{{STRUCTURE_2j8h| PDB=2j8h | SCENE= }}
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'''STRUCTURE OF THE IMMUNOGLOBULIN TANDEM REPEAT A168-A169 OF TITIN'''
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===STRUCTURE OF THE IMMUNOGLOBULIN TANDEM REPEAT A168-A169 OF TITIN===
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==Overview==
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Most of the structure of the giant muscle protein titin is formed by small modular domains. Many of them are predicted to be arranged in repeats with short linkers that may be key determinants of the peculiar elastic properties of titin. Here, we present the molecular structure of a tandem arrangement of two immunoglobulin-like domains, A168 and A169, located within the A-band segment of titin. The two domains are connected by a 17 residue long beta-strand and form a common interface. Based on these data, we establish general principles to estimate the amount of conformational flexibility of tandem domain motifs in titin. An unusual bulge within the second domain, A169, is directly involved into binding to a sarcomeric ligand, MURF-1, thus suggesting a dual role of this tandem for both the mechanical properties of titin and for sarcomeric signaling.
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{{ABSTRACT_PUBMED_17574571}}
==About this Structure==
==About this Structure==
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[[Category: Transferase]]
[[Category: Transferase]]
[[Category: Wd repeat]]
[[Category: Wd repeat]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 08:30:21 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 16:38:28 2008''

Revision as of 13:38, 27 July 2008

Image:2j8h.png

Template:STRUCTURE 2j8h

STRUCTURE OF THE IMMUNOGLOBULIN TANDEM REPEAT A168-A169 OF TITIN

Template:ABSTRACT PUBMED 17574571

About this Structure

2J8H is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Rigid conformation of an immunoglobulin domain tandem repeat in the A-band of the elastic muscle protein titin., Muller S, Lange S, Gautel M, Wilmanns M, J Mol Biol. 2007 Aug 10;371(2):469-80. Epub 2007 May 25. PMID:17574571

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