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2jgp

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{{STRUCTURE_2jgp| PDB=2jgp | SCENE= }}
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'''STRUCTURE OF THE TYCC5-6 PCP-C BIDOMAIN OF THE TYROCIDINE SYNTHETASE TYCC'''
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===STRUCTURE OF THE TYCC5-6 PCP-C BIDOMAIN OF THE TYROCIDINE SYNTHETASE TYCC===
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==Overview==
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The crystal structure of the bidomain PCP-C from modules 5 and 6 of the nonribosomal tyrocidine synthetase TycC was determined at 1.8 A resolution. The bidomain structure reveals a V-shaped condensation domain, the canyon-like active site groove of which is associated with the preceding peptidyl carrier protein (PCP) domain at its donor side. The relative arrangement of the PCP and the peptide bond-forming condensation (C) domain places the active sites approximately 50 A apart. Accordingly, this PCP-C structure represents a conformational state prior to peptide transfer from the donor-PCP to the acceptor-PCP domain, implying the existence of additional states of PCP-C domain interaction during catalysis. Additionally, PCP-C exerts a mode of cyclization activity that mimics peptide bond formation catalyzed by C domains. Based on mutational data and pK value analysis of active site residues, it is suggested that nonribosomal peptide bond formation depends on electrostatic interactions rather than on general acid/base catalysis.
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{{ABSTRACT_PUBMED_17637339}}
==About this Structure==
==About this Structure==
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[[Category: Phosphopantetheine]]
[[Category: Phosphopantetheine]]
[[Category: Tyrocidine]]
[[Category: Tyrocidine]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 08:53:16 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 08:57:07 2008''

Revision as of 05:57, 29 July 2008

Image:2jgp.png

Template:STRUCTURE 2jgp

STRUCTURE OF THE TYCC5-6 PCP-C BIDOMAIN OF THE TYROCIDINE SYNTHETASE TYCC

Template:ABSTRACT PUBMED 17637339

About this Structure

2JGP is a Single protein structure of sequence from Brevibacillus brevis. Full crystallographic information is available from OCA.

Reference

Structural and functional insights into a peptide bond-forming bidomain from a nonribosomal peptide synthetase., Samel SA, Schoenafinger G, Knappe TA, Marahiel MA, Essen LO, Structure. 2007 Jul;15(7):781-92. PMID:17637339

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