2jhb

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{{STRUCTURE_2jhb| PDB=2jhb | SCENE= }}
{{STRUCTURE_2jhb| PDB=2jhb | SCENE= }}
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'''CORE BINDING FACTOR BETA'''
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===CORE BINDING FACTOR BETA===
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==Overview==
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The core binding factor beta subunit (CBF beta) is the non-DNA binding subunit of the core-binding factors, transcription factors essential for multiple developmental processes including hematopoiesis and bone development. Chromosomal translocations involving the human CBFB gene are associated with a large percentage of human leukemias. The N-terminal 141 amino acids of CBF beta contains the heterodimerization domain for the DNA-binding CBF alpha subunits, and is sufficient for CBF beta function in vivo. Here we present the high-resolution solution structure of the CBF beta heterodimerization domain. It is a novel alpha/beta structure consisting of two three-stranded beta-sheets packed on one another in a sandwich arrangement, with four peripheral alpha-helices. The CBF alpha binding site on CBF beta has been mapped by chemical shift perturbation analysis.
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(as it appears on PubMed at http://www.pubmed.gov), where 10404216 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10404216}}
==About this Structure==
==About this Structure==
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2JHB is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JHB OCA].
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2JHB is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JHB OCA].
==Reference==
==Reference==
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[[Category: Core binding factor]]
[[Category: Core binding factor]]
[[Category: Transcription factor]]
[[Category: Transcription factor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 08:55:14 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 00:25:56 2008''

Revision as of 21:26, 28 July 2008

Image:2jhb.png

Template:STRUCTURE 2jhb

CORE BINDING FACTOR BETA

Template:ABSTRACT PUBMED 10404216

About this Structure

2JHB is a Single protein structure of sequence from Mus musculus. Full experimental information is available from OCA.

Reference

Solution structure of core binding factor beta and map of the CBF alpha binding site., Huang X, Peng JW, Speck NA, Bushweller JH, Nat Struct Biol. 1999 Jul;6(7):624-7. PMID:10404216

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