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6fit
From Proteopedia
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| - | [[Image:6fit. | + | [[Image:6fit.jpg|left|200px]]<br /><applet load="6fit" size="450" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="6fit" size="450" color="white" frame="true" align="right" spinBox="true" | + | |
caption="6fit, resolution 2.6Å" /> | caption="6fit, resolution 2.6Å" /> | ||
'''FHIT-TRANSITION STATE ANALOG'''<br /> | '''FHIT-TRANSITION STATE ANALOG'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 6FIT is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with AMW as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Bis(5'-adenosyl)-triphosphatase Bis(5'-adenosyl)-triphosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.29 3.6.1.29] | + | 6FIT is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with AMW as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Bis(5'-adenosyl)-triphosphatase Bis(5'-adenosyl)-triphosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.29 3.6.1.29] Known structural/functional Sites: <scene name='pdbsite=AVE:Active Site HIS Responsible For Forming The Transient Nu ...'>AVE</scene> and <scene name='pdbsite=HNE:HIS Triad For Which This Family Was Named'>HNE</scene>. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=6FIT OCA]. |
==Reference== | ==Reference== | ||
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[[Category: putative tumor suppressor]] | [[Category: putative tumor suppressor]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Dec 18 20:47:17 2007'' |
Revision as of 18:37, 18 December 2007
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FHIT-TRANSITION STATE ANALOG
Overview
The histidine triad (HIT) protein family is among the most ubiquitous and, highly conserved in nature, but a biological activity has not yet been, identified for any member of the HIT family. Fragile histidine triad, protein (FHIT) and protein kinase C interacting protein (PKCI) were used, in a structure-based approach to elucidate characteristics of in vivo, ligands and reactions. Crystallographic structures of apo, substrate, analog, pentacovalent transition-state analog, and product states of both, enzymes reveal a catalytic mechanism and define substrate characteristics, required for catalysis, thus unifying the HIT family as nucleotidyl, hydrolases, transferases, or both. The approach described here may be, useful in identifying structure-function relations between protein, families identified through genomics.
About this Structure
6FIT is a Single protein structure of sequence from Homo sapiens with AMW as ligand. Active as Bis(5'-adenosyl)-triphosphatase, with EC number 3.6.1.29 Known structural/functional Sites: and . Full crystallographic information is available from OCA.
Reference
Structure-based analysis of catalysis and substrate definition in the HIT protein family., Lima CD, Klein MG, Hendrickson WA, Science. 1997 Oct 10;278(5336):286-90. PMID:9323207
Page seeded by OCA on Tue Dec 18 20:47:17 2007
Categories: Bis(5'-adenosyl)-triphosphatase | Homo sapiens | Single protein | Hendrickson, W.A. | Klein, M.G. | Lima, C.D. | AMW | Fhit | Fragile histidine triad protein | Histidine triad protein family | Hit protein family | Hydrolase | Nucleotidyl hydrolase | Nucleotidyl transferase | Putative tumor suppressor
